Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Rac1em1/Cya
Common Name:
Rac1-KO
Product ID:
S-KO-03990
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rac1-KO
Strain ID
KOCMP-19353-Rac1-B6J-VA
Gene Name
Rac1
Product ID
S-KO-03990
Gene Alias
D5Ertd559e
Background
C57BL/6JCya
NCBI ID
19353
Modification
Conventional knockout
Chromosome
5
Phenotype
MGI:97845
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rac1em1/Cya mice (Catalog S-KO-03990) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000100489
NCBI RefSeq
NM_001347530.1
Target Region
Exon 2~3
Size of Effective Region
~3.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rac1, also known as RAS-related C3 botulinum toxin substrate 1, is an important member of Rho GTPases. It acts as a cytoskeleton regulation protein, participating in key processes such as cell adhesion, morphology, and movement [2]. Rac1 is involved in numerous signaling networks, like the regulation of actin cytoskeleton remodeling, activation of protein kinases (PAKs, MAPKs) and transcription factors (NF-κB, Wnt/β-catenin/TCF, STAT3, Snail), and production of reactive oxygen species [4].

Rac1 is highly expressed in various tumors, promoting processes like the tumor cell cycle, apoptosis, proliferation, invasion, migration, angiogenesis, and the regulation of tumor stem cells [2]. In bladder pathologies, its overexpression and dysregulation are common, contributing to tumorigenesis, tumor progression, epithelial-mesenchymal transition, and metastasis [1]. In metastatic cutaneous melanoma, Rac1 activation is related to cancer migration, invasion, angiogenesis, and metastasis, with the RAC1P29S driver mutation appearing in many cases [5]. Small molecule inhibitors targeting Rac1, such as NSC23766, EHT 1864, GYS32661, and MBQ-167, have shown potential in treating cancers, especially chemoresistant ones [1,3].

In conclusion, Rac1 is crucial for normal cellular functions and is significantly involved in disease conditions, particularly cancers. Its overexpression and dysregulation in various tumors make it an attractive therapeutic target. The development and study of Rac1 inhibitors offer promise for better management of these diseases, highlighting the importance of understanding Rac1's functions through in-vivo studies like gene knockout (KO) or conditional knockout (CKO) mouse models, though the references did not specifically detail findings from such models in this regard [1-5].

References:

1. Sauzeau, Vincent, Beignet, Julien, Bailly, Christian. 2022. Rac1 as a Target to Treat Dysfunctions and Cancer of the Bladder. In Biomedicines, 10, . doi:10.3390/biomedicines10061357. https://pubmed.ncbi.nlm.nih.gov/35740379/

2. Liang, Jiaxin, Oyang, Linda, Rao, Shan, Zhou, Yujuan, Liao, Qianjin. 2021. Rac1, A Potential Target for Tumor Therapy. In Frontiers in oncology, 11, 674426. doi:10.3389/fonc.2021.674426. https://pubmed.ncbi.nlm.nih.gov/34079763/

3. Bailly, Christian, Beignet, Julien, Loirand, Gervaise, Sauzeau, Vincent. 2022. Rac1 as a therapeutic anticancer target: Promises and limitations. In Biochemical pharmacology, 203, 115180. doi:10.1016/j.bcp.2022.115180. https://pubmed.ncbi.nlm.nih.gov/35853497/

4. Kotelevets, Larissa, Chastre, Eric. 2020. Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis. In Cancers, 12, . doi:10.3390/cancers12030665. https://pubmed.ncbi.nlm.nih.gov/32178475/

5. Colón-Bolea, Paula, García-Gómez, Rocío, Casar, Berta. 2021. RAC1 Activation as a Potential Therapeutic Option in Metastatic Cutaneous Melanoma. In Biomolecules, 11, . doi:10.3390/biom11111554. https://pubmed.ncbi.nlm.nih.gov/34827551/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest