C57BL/6JCya-Rb1em1/Cya
Common Name:
Rb1-KO
Product ID:
S-KO-04049
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Rb1-KO
Strain ID
KOCMP-19645-Rb1-B6J-VA
Gene Name
Product ID
S-KO-04049
Gene Alias
Rb; Rb-1; p110-RB1; pRb; pp105
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
14
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Rb1em1/Cya mice (Catalog S-KO-04049) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022701
NCBI RefSeq
NM_009029
Target Region
Exon 3~16
Size of Effective Region
~34.6 kb
Detailed Document
Overview of Gene Research
Rb1, also known as the retinoblastoma susceptibility gene, is a prototype tumor suppressor gene. It plays a key role in restraining cell cycle entry and, along with its family members, regulates numerous cellular processes, ultimately determining cell fate. Alterations in the RB1 pathway occur in most human cancers and often have prognostic value. RB1 status is a crucial determinant of the cell response to antitumoral therapies, impacting the outcome of both traditional and modern anti-cancer strategies [1,3].
Mutation of the RB1 gene has been observed in multiple types of malignant tumors, including prostate cancer, lung cancer, breast cancer, and almost every familial and sporadic case of retinoblastoma. Research has focused on the mechanism underlying RB1 mutation during oncogenesis, and potential clinical strategies targeting RB1-mutated cancers have been discussed [1]. In addition, the loss of RB1 function drives tumorigenesis in limited types of malignancies such as retinoblastoma and small cell lung cancer. A variety of novel therapies have been proposed to target RB1 loss, for example, the inhibition of certain mitotic kinases appears to be synthetic lethal with RB1 deficiency [2].
In conclusion, RB1 is a vital tumor suppressor gene whose function is closely related to cell cycle regulation and cancer development. Studies on RB1-mutated or-deficient models, especially in relation to cancer, have provided valuable insights into the mechanisms of tumorigenesis and potential therapeutic strategies for cancers where RB1 function is compromised.
References:
1. Yao, Yiran, Gu, Xiang, Xu, Xiaofang, Ge, Shengfang, Jia, Renbing. 2022. Novel insights into RB1 mutation. In Cancer letters, 547, 215870. doi:10.1016/j.canlet.2022.215870. https://pubmed.ncbi.nlm.nih.gov/35964818/
2. Linn, Paing, Kohno, Susumu, Sheng, Jindan, Watanabe, Yoshihiro, Takahashi, Chiaki. 2021. Targeting RB1 Loss in Cancers. In Cancers, 13, . doi:10.3390/cancers13153737. https://pubmed.ncbi.nlm.nih.gov/34359636/
3. Indovina, Paola, Pentimalli, Francesca, Conti, Daniele, Giordano, Antonio. 2019. Translating RB1 predictive value in clinical cancer therapy: Are we there yet? In Biochemical pharmacology, 166, 323-334. doi:10.1016/j.bcp.2019.06.003. https://pubmed.ncbi.nlm.nih.gov/31176618/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen