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C57BL/6NCya-Rbp4em1/Cya
Common Name:
Rbp4-KO
Product ID:
S-KO-04060
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Rbp4-KO
Strain ID
KOCMP-19662-Rbp4-B6N-VA
Gene Name
Rbp4
Product ID
S-KO-04060
Gene Alias
Rbp-4
Background
C57BL/6NCya
NCBI ID
19662
Modification
Conventional knockout
Chromosome
19
Phenotype
MGI:97879
Document
Click here to download >>
Application
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More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Rbp4em1/Cya mice (Catalog S-KO-04060) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000025951
NCBI RefSeq
NM_001159487
Target Region
Exon 1~4
Size of Effective Region
~1.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Rbp4, or Retinol-binding protein 4, is a member of the lipocalin family and acts as a specific carrier protein that delivers retinol (vitamin A) from the liver to the peripheral tissues [3]. It is predominantly secreted in the liver and adipose tissues and has gained attention in metabolism research [1].

In recent years, numerous studies have explored the role of Rbp4 in various diseases. Elevated serum levels of Rbp4 in obese experimental animals and human subjects are associated with cardiometabolic diseases (CMD) such as obesity, insulin resistance, and hyperlipidemia [1]. Rbp4 has also been identified as a controversial adipokine, potentially linking obesity with its comorbidities like insulin resistance, type 2 diabetes (T2D), and components of the metabolic syndrome, though clinical data are conflicting [2]. In gestational diabetes mellitus (GDM), circulating Rbp4 levels are consistently higher in affected cases compared to non-GDM controls, suggesting its potential as a biomarker [3]. In T2DM patients with kidney diseases, Rbp4 concentrations are significantly higher in those with micro-or macro-albuminuria, and levels are positively correlated with the albumin-to-creatinine ratio but negatively correlated with the estimated glomerular filtration rate, indicating it could be a reliable biomarker for kidney diseases in T2DM [4]. Bariatric surgery in obese individuals impacts Rbp4 levels, and it may improve insulin sensitivity post-surgery, suggesting its potential as a pharmacotherapeutic target [5]. In hyperuricemia-induced rats and patients with hyperuricemia, Rbp4 may be involved in hyperuricemia-induced insulin resistance by inhibiting IRS/PI3K/Akt phosphorylation [6].

In conclusion, Rbp4 is crucial for retinol transport and has significant implications in multiple disease areas. Its role in cardiometabolic diseases, diabetes-related complications, and other conditions like hyperuricemia-induced insulin resistance has been increasingly recognized. The study of Rbp4 in these disease contexts helps in understanding disease mechanisms and potentially developing new therapeutic strategies. [1-6]

References:

1. Oluwamodupe, Cecilia, Adeleye, Adesola Oluwaseun. 2023. Targeting Retinol-Binding Protein 4 (RBP4) in the Management of Cardiometabolic Diseases. In Cardiovascular toxicology, 23, 285-294. doi:10.1007/s12012-023-09803-8. https://pubmed.ncbi.nlm.nih.gov/37587250/

2. Kotnik, Primoz, Fischer-Posovszky, Pamela, Wabitsch, Martin. 2011. RBP4: a controversial adipokine. In European journal of endocrinology, 165, 703-11. doi:10.1530/EJE-11-0431. https://pubmed.ncbi.nlm.nih.gov/21835764/

3. Leca, Bianca M, Kite, Chris, Lagojda, Lukasz, Randeva, Harpal S, Kyrou, Ioannis. 2024. Retinol-binding protein 4 (RBP4) circulating levels and gestational diabetes mellitus: a systematic review and meta-analysis. In Frontiers in public health, 12, 1348970. doi:10.3389/fpubh.2024.1348970. https://pubmed.ncbi.nlm.nih.gov/38532976/

4. Zhang, Li, Cheng, Yan-Li, Xue, Shuai, Xu, Zhong-Gao. 2020. The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis. In Disease markers, 2020, 8830471. doi:10.1155/2020/8830471. https://pubmed.ncbi.nlm.nih.gov/33082885/

5. Bidares, Matin, Safari-Kish, Borna, Malekzadeh-Shoushtari, Hesam, Nosouhi, Golnaz, Aziz, Mahsa. 2024. Assessing the Impact of Bariatric Surgery on Retinol-Binding Protein 4 (RBP4): A Systematic Review and Meta-Analysis. In Obesity surgery, 34, 1855-1865. doi:10.1007/s11695-024-07140-5. https://pubmed.ncbi.nlm.nih.gov/38451368/

6. Liu, Chan, Zhou, Xiao-Rong, Ye, Mu-Yao, Liu, Hong, Huang, Xian-Zhe. 2021. RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced Rats and Patients With Hyperuricemia. In Frontiers in endocrinology, 12, 653819. doi:10.3389/fendo.2021.653819. https://pubmed.ncbi.nlm.nih.gov/34177800/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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