C57BL/6JCya-Ccl17em1/Cya
Common Name
Ccl17-KO
Product ID
S-KO-04224
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20295-Ccl17-B6J-VA
When using this mouse strain in a publication, please cite “Ccl17-KO Mouse (Catalog S-KO-04224) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ccl17-KO
Strain ID
KOCMP-20295-Ccl17-B6J-VA
Gene Name
Product ID
S-KO-04224
Gene Alias
Abcd-2, Scya17, Scya17l, Tarc
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000034232
NCBI RefSeq
NM_011332
Target Region
Exon 1~3
Size of Effective Region
~2.0 kb
Overview of Gene Research
Ccl17, also known as thymus-and activation-regulated chemokine (TARC), is a C-C chemokine ligand that binds to C-C chemokine receptor type 4 (CCR4). It plays important roles in immune-related processes, especially in leukocyte recruitment and T-cell-driven diseases. Granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling is a key regulator of Ccl17 expression through cooperative activation of STAT5 and canonical NF-κB signaling [1,2].
Gene knockout studies have provided crucial insights. In Ccl17 knockout mice, reduced left ventricular (LV) remodeling, decreased myocardial fibrosis and cardiomyocyte hypertrophy, and improved LV systolic function were observed after myocardial infarction and angiotensin II and phenylephrine infusion. This was due to increased abundance of regulatory T cells (Tregs) in the myocardium, as Ccl17 inhibits Treg recruitment through biased activation of CCR4 [1]. In addition, Ccll7-KO significantly repressed aging and angiotensin II-induced cardiac hypertrophy and fibrosis, accompanied by the plasticity and differentiation of T cell subsets [3].
In conclusion, Ccl17 is a pro-inflammatory mediator involved in multiple disease processes. Gene knockout mouse models have revealed its role in myocardial injury, cardiac hypertrophy, and heart failure, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Feng, Guoshuai, Bajpai, Geetika, Ma, Pan, Kreisel, Daniel, Lavine, Kory J. 2022. CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells. In Circulation, 145, 765-782. doi:10.1161/CIRCULATIONAHA.121.055888. https://pubmed.ncbi.nlm.nih.gov/35113652/
2. Lupancu, Tanya J, Eivazitork, Mahtab, Hamilton, John A, Achuthan, Adrian A, Lee, Kevin M-C. 2023. CCL17/TARC in autoimmunity and inflammation-not just a T-cell chemokine. In Immunology and cell biology, 101, 600-609. doi:10.1111/imcb.12644. https://pubmed.ncbi.nlm.nih.gov/36975092/
3. Zhang, Yang, Ye, Yicong, Tang, Xiaoqiang, Tian, Zhuang, Zhang, Shuyang. 2022. CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure. In The Journal of experimental medicine, 219, . doi:10.1084/jem.20200418. https://pubmed.ncbi.nlm.nih.gov/35687056/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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