Slc4a1ap, also known as kanadaptin, is a protein-encoding gene. Kanadaptin was initially identified as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is widely expressed in mammalian tissues, and its transcripts are found in tissues not expressing kAE1, indicating additional functions [4,5,6]. It has a multidomain structure and contains nuclear localization sequences, suggesting it may have a role in nuclear signaling [6].

In a study screening housekeeping genes for use as internal controls in human non-cancerous kidney tissue, SLC4A1AP expression was found to be stable in all but one Fabry disease dataset among 30 expression datasets. This suggests it could be suitable for normalization purposes in non-cancerous kidney biopsies [1]. In a meta-analysis of blood pressure-associated loci, a missense variant (rs9678851) in SLC4A1AP was identified as a new blood pressure-associated locus, highlighting its potential role in blood pressure regulation [2]. In head and neck squamous cell carcinoma, SLC4A1AP was among the genes identified as having a survival impact in laryngopharyngeal cancer when correlated with perineural/angiolymphatic invasion [3].

In conclusion, Slc4a1ap has diverse potential functions. Its stable expression in non-cancerous kidney tissue makes it a candidate for normalization in relevant studies. The identification of its association with blood pressure and its role in head and neck squamous cell carcinoma highlight its importance in understanding these biological processes and diseases. Research on Slc4a1ap contributes to a better understanding of normal physiological functions and disease mechanisms.

References:

1. Strauss, Philipp, Mikkelsen, Håvard, Furriol, Jessica. 2021. Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies. In PloS one, 16, e0259373. doi:10.1371/journal.pone.0259373. https://pubmed.ncbi.nlm.nih.gov/34882702/

2. Kraja, Aldi T, Cook, James P, Warren, Helen R, Munroe, Patricia B, Howson, Joanna M M. . New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. In Circulation. Cardiovascular genetics, 10, . doi:10.1161/CIRCGENETICS.117.001778. https://pubmed.ncbi.nlm.nih.gov/29030403/

3. Reddy, Ram Bhupal, Khora, Samanta S, Suresh, Amritha. 2019. Molecular prognosticators in clinically and pathologically distinct cohorts of head and neck squamous cell carcinoma-A meta-analysis approach. In PloS one, 14, e0218989. doi:10.1371/journal.pone.0218989. https://pubmed.ncbi.nlm.nih.gov/31310629/

4. Hübner, Stefan, Bahr, Chris, Gössmann, Holger, Efthymiadis, Athina, Drenckhahn, Detlev. . Mitochondrial and nuclear localization of kanadaptin. In European journal of cell biology, 82, 240-52. doi:. https://pubmed.ncbi.nlm.nih.gov/12800979/

5. Chen, J, Vijayakumar, S, Li, X, Al-Awqati, Q. . Kanadaptin is a protein that interacts with the kidney but not the erythroid form of band 3. In The Journal of biological chemistry, 273, 1038-43. doi:. https://pubmed.ncbi.nlm.nih.gov/9422766/

6. Hübner, Stefan, Jans, David A, Xiao, Chong-Yun, John, Anna P, Drenckhahn, Detlev. . Signal- and importin-dependent nuclear targeting of the kidney anion exchanger 1-binding protein kanadaptin. In The Biochemical journal, 361, 287-96. doi:. https://pubmed.ncbi.nlm.nih.gov/11772400/