C57BL/6NCya-Sstem1/Cya
Common Name
Sst-KO
Product ID
S-KO-04389
Backgroud
C57BL/6NCya
Strain ID
KOCMP-20604-Sst-B6N-VA
When using this mouse strain in a publication, please cite “Sst-KO Mouse (Catalog S-KO-04389) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Sst-KO
Strain ID
KOCMP-20604-Sst-B6N-VA
Gene Name
Product ID
S-KO-04389
Gene Alias
SS, SOM, SRIF, Smst
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000004480
NCBI RefSeq
NM_009215
Target Region
Exon 1~2
Size of Effective Region
~1.0 kb
Overview of Gene Research
Sst, short for somatostatin, is a cyclic peptide that inhibits the release of hormones and neurotransmitters by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5) [3,4]. It negatively regulates cell proliferation and the release of multiple hormones, and is involved in the GH-IGF-SST system which plays a crucial role in liver growth, development and hepatocarcinogenesis [2,4]. Genetically modified mouse models are valuable for studying Sst's functions.
In mice, excitatory SST neurons in the medial paralemniscal nucleus (MPLSST neurons) promote self-grooming and encode reward. Loss of function of MPLSST neurons impairs both self-grooming and post-stress anxiety alleviation, revealing a dual role of the CeA-MPLSST-VTADA circuit in self-grooming and post-stress anxiety regulation [1].
In conclusion, Sst is important for regulating hormone release, cell proliferation and is involved in anxiety-related behaviors as demonstrated by mouse models. Understanding Sst's functions can potentially provide insights into the mechanisms of stress-related disorders and hepatocarcinogenesis.
References:
1. Sun, Jingjing, Yuan, Yuan, Wu, Xiaohua, Xu, Tian-Le, Huang, Ju. 2022. Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward. In Neuron, 110, 3356-3373.e8. doi:10.1016/j.neuron.2022.08.010. https://pubmed.ncbi.nlm.nih.gov/36070748/
2. Pivonello, Claudia, De Martino, Maria Cristina, Negri, Mariarosaria, Colao, Annamaria, Pivonello, Rosario. 2014. The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets. In Infectious agents and cancer, 9, 27. doi:10.1186/1750-9378-9-27. https://pubmed.ncbi.nlm.nih.gov/25225571/
3. Solarski, Michael, Williams, Declan, Mehrabian, Mohadeseh, Wille, Holger, Schmitt-Ulms, Gerold. 2019. The human brain somatostatin interactome: SST binds selectively to P-type family ATPases. In PloS one, 14, e0217392. doi:10.1371/journal.pone.0217392. https://pubmed.ncbi.nlm.nih.gov/31136617/
4. Sun, Lichun, Coy, David H. . Somatostatin and its Analogs. In Current drug targets, 17, 529-37. doi:. https://pubmed.ncbi.nlm.nih.gov/26951062/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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