Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Ccdc154em1/Cya
Common Name:
Ccdc154-KO
Product ID:
S-KO-04447
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ccdc154-KO
Strain ID
KOCMP-207209-Ccdc154-B6N-VA
Gene Name
Ccdc154
Product ID
S-KO-04447
Gene Alias
Ccdc157; Gm317; ntl
Background
C57BL/6NCya
NCBI ID
207209
Modification
Conventional knockout
Chromosome
17
Phenotype
MGI:2685163
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ccdc154em1/Cya mice (Catalog S-KO-04447) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000182621
NCBI RefSeq
NM_001079929
Target Region
Exon 2~9
Size of Effective Region
~4.9 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ccdc154, Coiled-Coil Domain-Containing 154, is a gene with diverse functions. It is involved in cell cycle regulation as overexpression can induce G2/M arrest, and is related to osteopetrosis-a skeletal bone disorder [4]. It may also participate in pathways relevant to cancer development and neurodegenerative diseases based on its association with processes like cell proliferation, metastasis in cancer, and its role as a potential biomarker in Parkinson's disease [2,3,5].

In a mouse model, a spontaneous mutation of Ccdc154 led to congenital deafness in homozygous mutant mice. These mice showed abnormal bony remodeling of the otic capsule, characterized by increased vascularization and multiple cavitary lesions, while the structure of the organ of Corti, hair cells, and spiral ganglion neurons remained normal. This indicates that Ccdc154 mutation-induced bony remodeling disorders in the auditory ossicles and otic capsule are involved in hearing loss [1]. In liver cancer cells, knockdown of Ccdc154 inhibited proliferation, migration, invasion, and increased apoptosis, potentially through reducing Snail expression [2]. In colorectal cancer, high expression of Ccdc154 was associated with poor survival, and it interacted with MCM2 to promote the malignant phenotype [3].

In conclusion, Ccdc154 is crucial in cell cycle regulation, bone remodeling, and is involved in the development of certain cancers. Mouse models, especially those with Ccdc154 mutations, have revealed its role in syndromic hereditary deafness. Its study in cancer cell lines has provided insights into its function in cancer development, contributing to our understanding of these biological processes and associated disease mechanisms [1,2,3,4].

References:

1. Xu, Kai, Bai, Xue, Chen, Sen, Li, He, Sun, Yu. 2021. CCDC154 Mutant Caused Abnormal Remodeling of the Otic Capsule and Hearing Loss in Mice. In Frontiers in cell and developmental biology, 9, 637011. doi:10.3389/fcell.2021.637011. https://pubmed.ncbi.nlm.nih.gov/33614666/

2. Ma, Rulan, Nie, Hongmei, Mo, Caijing, Zhu, Kun, Li, Kang. 2025. CCDC154 knockdown inhibits growth of liver cancer via suppressing expression of Snail. In European journal of medical research, 30, 59. doi:10.1186/s40001-025-02290-3. https://pubmed.ncbi.nlm.nih.gov/39885494/

3. Hong, Wei-Feng, Zhu, De-Xiang, Chen, Yan-Jie, Liu, Tian-Shu, Liang, Li. 2023. Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2. In Cancer letters, 578, 216460. doi:10.1016/j.canlet.2023.216460. https://pubmed.ncbi.nlm.nih.gov/37863352/

4. Liao, Wanqin, Zhao, Rongsen, Lu, Liting, Deng, Yuezhen, Lu, Xincheng. 2012. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. In Cell cycle (Georgetown, Tex.), 11, 3270-9. doi:10.4161/cc.21642. https://pubmed.ncbi.nlm.nih.gov/22895184/

5. Dong, Wenwen, Qiu, Chang, Gong, Dawei, Zhang, Li, Zhang, Wenbin. 2019. Proteomics and bioinformatics approaches for the identification of plasma biomarkers to detect Parkinson's disease. In Experimental and therapeutic medicine, 18, 2833-2842. doi:10.3892/etm.2019.7888. https://pubmed.ncbi.nlm.nih.gov/31572530/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest