C57BL/6NCya-Scarb1em1/Cya
Common Name
Scarb1-KO
Product ID
S-KO-04499
Backgroud
C57BL/6NCya
Strain ID
KOCMP-20778-Scarb1-B6N-VA
When using this mouse strain in a publication, please cite “Scarb1-KO Mouse (Catalog S-KO-04499) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Scarb1-KO
Strain ID
KOCMP-20778-Scarb1-B6N-VA
Gene Name
Product ID
S-KO-04499
Gene Alias
CD36, Cd36l1, Chohd1, Cla-1, Cla1, D5Ertd460e, Hdlq1, Hlb398, SR-B1, SR-BI, SRBI, Srb1, mSR-BI
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000086075
NCBI RefSeq
NM_016741
Target Region
Exon 2~9
Size of Effective Region
~17.2 kb
Overview of Gene Research
Scarb1, encoding scavenger receptor class B type 1 (SR-B1), is a lipoprotein receptor. SR-B1 binds to high-density lipoprotein (HDL) and low-density lipoprotein (LDL), and is also a receptor for lipoprotein (a) (Lp(a)). It plays a crucial role in lipid metabolism, mediating the cellular uptake of cholesterol and promoting the clearance of Lp(a) [3]. Genetic association studies of Scarb1 contribute to understanding its function in vivo [1].
Candidate gene studies have identified Scarb1 as significantly associated with high HDL-C and increased myocardial infarction (MI) risk, indicating its role in cardiovascular-related conditions [1]. A meta-analysis of the rs5888 polymorphism of Scarb1 suggested a negative association with coronary heart disease (CHD), especially in males [2]. Functional studies of Scarb1 variants showed decreased receptor function in vitro, and these variants are associated with a new lipid phenotype of high HDL-cholesterol and high Lp(a) [3]. Also, Scarb1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area [4].
In summary, Scarb1 is essential in lipid metabolism, with its variants and polymorphisms having associations with various diseases, especially cardiovascular and age-related macular degeneration. Studies on Scarb1 contribute to understanding the molecular mechanisms underlying these diseases, potentially providing new directions for prevention and treatment.
References:
1. Rodriguez, Annabelle. 2021. High HDL-Cholesterol Paradox: SCARB1-LAG3-HDL Axis. In Current atherosclerosis reports, 23, 5. doi:10.1007/s11883-020-00902-3. https://pubmed.ncbi.nlm.nih.gov/33398433/
2. Ma, Ruchao, Zhu, Xiaoyun, Yan, Bo. 2018. SCARB1 rs5888 gene polymorphisms in coronary heart disease: A systematic review and a meta-analysis. In Gene, 678, 280-287. doi:10.1016/j.gene.2018.08.024. https://pubmed.ncbi.nlm.nih.gov/30103009/
3. Yang, Xiaoping, Sethi, Amar, Yanek, Lisa R, Remaley, Alan T, Becker, Lewis C. 2016. SCARB1 Gene Variants Are Associated With the Phenotype of Combined High High-Density Lipoprotein Cholesterol and High Lipoprotein (a). In Circulation. Cardiovascular genetics, 9, 408-418. doi:. https://pubmed.ncbi.nlm.nih.gov/27651445/
4. Stanislovaitiene, Daiva, Zaliuniene, Dalia, Krisciukaitis, Algimantas, Tamosiunas, Abdonas, Lesauskaite, Vaiva. 2016. SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area. In Ophthalmic genetics, 38, 233-237. doi:10.1080/13816810.2016.1203442. https://pubmed.ncbi.nlm.nih.gov/27428740/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.