C57BL/6JCya-Surf2em1/Cya
Common Name
Surf2-KO
Product ID
S-KO-04653
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20931-Surf2-B6J-VA
When using this mouse strain in a publication, please cite “Surf2-KO Mouse (Catalog S-KO-04653) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Surf2-KO
Strain ID
KOCMP-20931-Surf2-B6J-VA
Gene Name
Product ID
S-KO-04653
Gene Alias
Surf-2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000015017
NCBI RefSeq
NM_013678
Target Region
Exon 4~5
Size of Effective Region
~0.8 kb
Overview of Gene Research
Surf2, part of the Surfeit locus genes, is involved in multiple biological processes. It has a bidirectional promoter with Surf-1, and they are divergently transcribed [3,4]. In the nucleolar stress response, Surf2 buffers free 5S ribonucleoprotein (RNP) particles, modulating their activity. Its depletion increases cellular sensitivity to nucleolar stress, while overexpression promotes resistance. Also, Surf2 is overexpressed in many cancers and is an independent prognostic marker for adrenocortical cancer [1].
In the context of Alzheimer's disease (AD), through the integration of genomics and transcriptomics, it was found that an increase in Surf2 expression was associated with a significantly decreased risk of AD [2].
In summary, Surf2 is crucial in processes like the nucleolar stress response and may have a protective role in AD. Studies on Surf2, especially through gene-related models, contribute to understanding its functions in cancer and neurodegenerative diseases, potentially offering new therapeutic targets and insights into disease mechanisms.
References:
1. Tagnères, Sophie, Santo, Paulo Espirito, Radermecker, Julie, Plisson-Chastang, Célia, Lebaron, Simon. 2024. SURF2 is a MDM2 antagonist in triggering the nucleolar stress response. In Nature communications, 15, 8404. doi:10.1038/s41467-024-52659-x. https://pubmed.ncbi.nlm.nih.gov/39333141/
2. OuYang, Chenghong, Shi, Hanping, Lin, Zhiying. 2025. Identification of Alzheimer's disease susceptibility genes by the integration of genomics and transcriptomics. In Neurological research, , 1-13. doi:10.1080/01616412.2025.2499890. https://pubmed.ncbi.nlm.nih.gov/40331660/
3. Lennard, A C, Fried, M. . The bidirectional promoter of the divergently transcribed mouse Surf-1 and Surf-2 genes. In Molecular and cellular biology, 11, 1281-94. doi:. https://pubmed.ncbi.nlm.nih.gov/1996091/
4. Williams, T J, Fried, M. . The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. In Molecular and cellular biology, 6, 4558-69. doi:. https://pubmed.ncbi.nlm.nih.gov/3025660/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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