C57BL/6JCya-Taar4em1/Cya
Common Name
Taar4-KO
Product ID
S-KO-04679
Backgroud
C57BL/6JCya
Strain ID
KOCMP-209513-Taar4-B6J-VA
When using this mouse strain in a publication, please cite “Taar4-KO Mouse (Catalog S-KO-04679) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Taar4-KO
Strain ID
KOCMP-209513-Taar4-B6J-VA
Gene Name
Product ID
S-KO-04679
Gene Alias
Gm226, Ta2, taR-4
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000092660
NCBI RefSeq
NM_001008499
Target Region
Exon 1
Size of Effective Region
~2.1 kb
Overview of Gene Research
Taar4, a member of the trace amine-associated receptor (TAAR) family, is a G Protein-Coupled Receptor functioning as an olfactory receptor in vertebrates. It is involved in the detection of certain volatile amines, and its activation can trigger innate behavioral responses. In mice, it is associated with the aversive response to the predator odor 2-phenylethylamine, indicating its role in predator-prey interactions and survival-related olfactory functions [1,2,4].
Genetic deletion of Taar4 in mice has been a crucial research model. The knockout (KO) of Taar4 eliminates the aversion that mice display to low concentrations of volatile amines and to the odour of predator urine. This finding from the KO mouse model reveals that Taar4 contributes substantially to the non-redundant coding of aversive odours in the main olfactory pathway, highlighting its key role in high-sensitivity detection of innately aversive odours [3].
In conclusion, Taar4 plays an essential role in olfaction, specifically in the detection of aversive odours. The Taar4 KO mouse model has been instrumental in uncovering its function in predator-related olfactory responses, providing insights into the mechanisms underlying innate aversive odor perception, which may be relevant in understanding survival-related behaviors in mammals.
References:
1. Liberles, Stephen D. 2015. Trace amine-associated receptors: ligands, neural circuits, and behaviors. In Current opinion in neurobiology, 34, 1-7. doi:10.1016/j.conb.2015.01.001. https://pubmed.ncbi.nlm.nih.gov/25616211/
2. Li, Qian. . Deorphanization of Olfactory Trace Amine-Associated Receptors. In Methods in molecular biology (Clifton, N.J.), 1820, 21-31. doi:10.1007/978-1-4939-8609-5_2. https://pubmed.ncbi.nlm.nih.gov/29884934/
3. Dewan, Adam, Pacifico, Rodrigo, Zhan, Ross, Rinberg, Dmitry, Bozza, Thomas. 2013. Non-redundant coding of aversive odours in the main olfactory pathway. In Nature, 497, 486-9. doi:10.1038/nature12114. https://pubmed.ncbi.nlm.nih.gov/23624375/
4. Qian, Kang-Ying, Hao, Yue, Li, Qian. . Deorphanization of Olfactory Trace Amine-Associated Receptors. In Methods in molecular biology (Clifton, N.J.), 2915, 201-212. doi:10.1007/978-1-0716-4466-9_14. https://pubmed.ncbi.nlm.nih.gov/40249494/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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