C57BL/6NCya-Iglon5em1/Cya
Common Name
Iglon5-KO
Product ID
S-KO-04721
Backgroud
C57BL/6NCya
Strain ID
KOCMP-210094-Iglon5-B6N-VA
When using this mouse strain in a publication, please cite “Iglon5-KO Mouse (Catalog S-KO-04721) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Iglon5-KO
Strain ID
KOCMP-210094-Iglon5-B6N-VA
Gene Name
Product ID
S-KO-04721
Gene Alias
A230106M20Rik, Gm1431
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000107974
NCBI RefSeq
NM_001164518
Target Region
Exon 2~6
Size of Effective Region
~4.1 kb
Overview of Gene Research
IgLON5, a gene encoding a cell adhesion molecule, is involved in cell-cell interactions and plays a role in the nervous system. It may participate in pathways related to neuronal development, function, and communication. Understanding its function is crucial for insights into normal neural processes and related disorders [1-10].
Anti-IgLON5 disease is an autoimmune disorder associated with autoantibodies against IgLON5. It has a broad clinical spectrum, including sleep disorders, bulbar symptoms, movement disorders, and cognitive decline. The disease shows characteristics of both autoimmunity and neurodegeneration. Neuropathological examination reveals a tauopathy preferentially affecting the hypothalamus and brainstem tegmentum. Basic studies suggest that IgLON5 antibody-induced neuronal damage is irreversible, indicating a potential link between autoimmunity and neurodegeneration [1,2,3]. Low levels of neurofilament light chain in serum and cerebrospinal fluid at disease onset could be a predictor of immunotherapy response [2].
In conclusion, IgLON5 is important for normal nervous system function. Studies on anti-IgLON5 disease, though not directly from KO/CKO mouse models in the provided references, have shown that IgLON5 autoantibodies are associated with a complex disorder with features of autoimmunity and neurodegeneration. Understanding IgLON5 is key to further exploring the pathogenesis of this disease and potentially developing better treatment strategies [1,2,3].
References:
1. Zhang, Yi-Zong Heng, Ni, You, Gao, Yi-Ning, Hu, Ji, Chen, Sheng. . Anti-IgLON5 disease: a novel topic beyond neuroimmunology. In Neural regeneration research, 18, 1017-1022. doi:10.4103/1673-5374.355742. https://pubmed.ncbi.nlm.nih.gov/36254983/
2. Gaig, Carles, Sabater, Lidia. 2024. New knowledge on anti-IgLON5 disease. In Current opinion in neurology, 37, 316-321. doi:10.1097/WCO.0000000000001271. https://pubmed.ncbi.nlm.nih.gov/38563128/
3. Graus, Francesc, Sabater, Lidia, Gaig, Carles, Dalmau, Josep O, Santamaria, Joan. 2024. Anti-IgLON5 Disease 10 Years Later: What We Know and What We Do Not Know. In Neurology(R) neuroimmunology & neuroinflammation, 12, e200353. doi:10.1212/NXI.0000000000200353. https://pubmed.ncbi.nlm.nih.gov/39705634/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.