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C57BL/6NCya-Ccdc110em1/Cya
Common Name:
Ccdc110-KO
Product ID:
S-KO-04844
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ccdc110-KO
Strain ID
KOCMP-212392-Ccdc110-B6N-VA
Gene Name
Ccdc110
Product ID
S-KO-04844
Gene Alias
Gm172
Background
C57BL/6NCya
NCBI ID
212392
Modification
Conventional knockout
Chromosome
8
Phenotype
MGI:2685018
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Ccdc110em1/Cya mice (Catalog S-KO-04844) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000095326
NCBI RefSeq
NM_001033246
Target Region
Exon 5~6
Size of Effective Region
~3.0 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ccdc110, also known as KM-HN-1, is a protein-coding gene. It contains a C-terminal coiled-coil domain (CCD), a nuclear localization signal sequence, and a leucine zipper motif. It was previously discovered as a member of the human cancer/testis antigen (CTA). Although its full function remains to be fully identified, it has been implicated in cell cycle progression [1].

In a study, Tet-inducible overexpression of CCDC110 protein in U2-OS osteosarcoma cells delayed the entry of the G2/M phase, suggesting its role in cell cycle regulation [1]. Additionally, in a largely Hispanic population, maternal diabetes was associated with differential methylation of CCDC110 in newborns, indicating a potential link between maternal conditions and fetal epigenetic changes related to Ccdc110 [2]. In a genome-wide analysis of northern Chinese twins, 2 SNPs located in CCDC110 were related to the FEV1/FVC ratio, suggesting its association with pulmonary function [3]. An exome-wide association study in the UK Biobank detected CCDC110 in a burden test for anxiety, indicating a possible role in anxiety-related genetics [4].

In conclusion, Ccdc110 appears to be involved in cell cycle progression, may be affected by maternal diabetes through epigenetic changes, and shows associations with pulmonary function and anxiety. Studies on Ccdc110 contribute to understanding biological processes related to cell cycle, fetal development, pulmonary function, and mental health [1,2,3,4].

References:

1. Lee, Sue Nyoung, Hong, Kyeong-Man, Seong, Yeon Sun, Kwak, Sahng-June. 2020. Ectopic Overexpression of Coiled-Coil Domain Containing 110 Delays G2/M Entry in U2-OS Cells. In Development & reproduction, 24, 101-111. doi:10.12717/DR.2020.24.2.101. https://pubmed.ncbi.nlm.nih.gov/32734127/

2. Rizzo, Heather E, Escaname, Elia N, Alana, Nicholas B, Carr, Nicholas R, Blanco, Cynthia L. 2020. Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population. In Clinical epigenetics, 12, 34. doi:10.1186/s13148-020-0824-9. https://pubmed.ncbi.nlm.nih.gov/32075680/

3. Wang, Tong, Wang, Weijing, Xu, Chunsheng, Tian, Xiaocao, Zhang, Dongfeng. 2024. Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function. In BMC genomics, 25, 1255. doi:10.1186/s12864-024-11165-6. https://pubmed.ncbi.nlm.nih.gov/39736507/

4. Pan, Chuyu, Cheng, Shiqiang, Liu, Li, Jia, Yumeng, Zhang, Feng. 2023. Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank. In Progress in neuro-psychopharmacology & biological psychiatry, 130, 110928. doi:10.1016/j.pnpbp.2023.110928. https://pubmed.ncbi.nlm.nih.gov/38154517/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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