C57BL/6JCya-Tcte2em1/Cya
Common Name:
Tcte2-KO
Product ID:
S-KO-05176
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tcte2-KO
Strain ID
KOCMP-21646-Tcte2-B6J-VA
Gene Name
Product ID
S-KO-05176
Gene Alias
Tcte-2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tcte2em1/Cya mice (Catalog S-KO-05176) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000148430
NCBI RefSeq
--
Target Region
Exon 2~3
Size of Effective Region
~12.6 kb
Detailed Document
Overview of Gene Research
Tcte2, or t complex testes expressed 2, is a male meiosis-specific gene located on band 3.3 of mouse chromosome 17. It is crucial for normal male meiosis, with its function potentially linked to pathways involved in male fertility. Genetic models, especially mouse models, are valuable for studying its role in male reproductive processes [1].
The Tcte2 gene expresses a coding mRNA and several putative non-ORF transcripts during meiosis I. A deletion of the 5' part of the locus on the t haplotype form of chromosome 17 abolishes Tcte2 expression. Also, the non-ORF RNAs at the Tcte2 locus are differentially spliced in species that show hybrid sterility when crossed with laboratory mice. These findings suggest Tcte2 alleles as candidates for loci contributing to both meiotic drive and hybrid sterility phenotypes [1].
In conclusion, Tcte2 is essential for male meiosis. The identification of its role through studies in mouse models, such as the deletion-based observations, provides insights into the molecular mechanisms underlying male fertility-related issues like meiotic drive and hybrid sterility. Understanding Tcte2's function may contribute to a better understanding of male reproductive biology and potentially related infertility conditions [1].
References:
1. Braidotti, G, Barlow, D P. . Identification of a male meiosis-specific gene, Tcte2, which is differentially spliced in species that form sterile hybrids with laboratory mice and deleted in t chromosomes showing meiotic drive. In Developmental biology, 186, 85-99. doi:. https://pubmed.ncbi.nlm.nih.gov/9188755/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen