C57BL/6JCya-Adamts2em1/Cya
Common Name
Adamts2-KO
Product ID
S-KO-05196
Backgroud
C57BL/6JCya
Strain ID
KOCMP-216725-Adamts2-B6J-VA
When using this mouse strain in a publication, please cite “Adamts2-KO Mouse (Catalog S-KO-05196) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Adamts2-KO
Strain ID
KOCMP-216725-Adamts2-B6J-VA
Gene Name
Product ID
S-KO-05196
Gene Alias
ADAM-TS 2, ADAM-TS2, ADAMTS-2, PC I-NP, PCINP, pNPI
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000040523
NCBI RefSeq
NM_175643.3
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
ADAMTS2, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) superfamily, is a zinc metalloendopeptidase. It has key functions in extracellular matrix (ECM) remodeling, and is involved in multiple biological pathways such as TGF-β signaling. It is of great biological importance as it contributes to processes like neuronal migration, lymphatic homeostasis, and myofibroblast differentiation [1,2,3]. Genetic models, especially KO mouse models, are valuable in studying its functions.
In the developing neocortex, Adamts2 knockout suppresses the multipolar-to-bipolar transition of migrating neurons and disturbs radial migration, suggesting it promotes radial migration by activating TGF-β signaling [1]. In adult mice, Adamts2 knockout leads to skin lymphedema due to reduced lymphatic vessel density and diameter, indicating its role in pro-VEGFC activation and lymphatic homeostasis [2]. In pancreatic cancer-related studies, loss of Adamts2 reduces myofibroblast differentiation and invasion, with ADAMTS2 regulating myofibroblast differentiation through its role in the regulation of transforming growth factor β availability [3].
In summary, ADAMTS2 is crucial for ECM-related biological processes. KO mouse models have revealed its significance in neocortex development, lymphatic vasculature homeostasis, and pancreatic cancer-associated stromal behavior. Understanding ADAMTS2's functions provides insights into these biological processes and related disease mechanisms.
References:
1. Kaneko, Noe, Hirai, Kumiko, Oshima, Minori, Maeda, Nobuaki, Ohtaka-Maruyama, Chiaki. 2024. ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex. In EMBO reports, 25, 3090-3115. doi:10.1038/s44319-024-00174-x. https://pubmed.ncbi.nlm.nih.gov/38871984/
2. Dupont, Laura, Joannes, Loïc, Morfoisse, Florent, Noël, Agnès, Colige, Alain Cma. 2022. ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis. In JCI insight, 7, . doi:10.1172/jci.insight.151509. https://pubmed.ncbi.nlm.nih.gov/35316211/
3. Carter, Edward P, Yoneten, Kubra K, Gavara, Nuria, Pearce, Oliver, Grose, Richard P. 2023. Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. In The Journal of pathology, 262, 90-104. doi:10.1002/path.6214. https://pubmed.ncbi.nlm.nih.gov/37929635/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.