Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Tspan7em1/Cya
Common Name:
Tspan7-KO
Product ID:
S-KO-05484
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tspan7-KO
Strain ID
KOCMP-21912-Tspan7-B6J-VA
Gene Name
Tspan7
Product ID
S-KO-05484
Gene Alias
1200014P11Rik; A15; Cd231; Mxs1; PE31; TALLA; Tm4sf2
Background
C57BL/6JCya
NCBI ID
21912
Modification
Conventional knockout
Chromosome
X
Phenotype
MGI:1298407
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tspan7em1/Cya mice (Catalog S-KO-05484) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000076354
NCBI RefSeq
NM_019634
Target Region
Exon 2~5
Size of Effective Region
~6.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
TSPAN7, a member of the tetraspanin family, has diverse functions. It acts as a positive regulator of actin nucleation and stabilization via the ARP2/3 complex, influencing processes like the transfer of HIV-1 from dendritic cells to T lymphocytes [1,8]. It also seems to be involved in the regulation of cell-cell interactions, cytoskeletal organization, and may impact various cellular functions related to development, immunity, and cancer [1,2,3,4,5,6,7,8,9,10]. Genetic models, such as knockout models, can be valuable for studying its role in more detail.

In Tspan7 knockout rats, ASD-like and ID-like behavioral phenotypes were observed, along with brain structure alterations and related pathological changes. The integrin β1/FAK/SRC signal pathway was interrupted, leading to down-regulation of key synaptic integrity-related proteins [7]. In glioma, TSPAN7 expression was decreased in high-grade gliomas, and low expression was associated with poor prognosis. Overexpression of TSPAN7 in glioma cell lines explored its anti-tumor role [2]. In bladder cancer, down-regulation of TSPAN7 was seen in tissues and cell lines, and overexpression in nude mice affected tumor growth via the PTEN/PI3K/AKT pathway [3]. In lung cancer, TSPAN7 promoted cell migration and proliferation via epithelial-to-mesenchymal transition [6]. In zebrafish, Tspan7 was required for migrasome formation, and its mutants showed impaired organ morphogenesis [5].

In conclusion, TSPAN7 is involved in a wide range of biological functions, including immune-related processes, organ morphogenesis, and synaptic function. Its role in diseases such as glioma, bladder cancer, lung cancer, and autism-spectrum disorder has been revealed through knockout models and other functional studies. These findings contribute to understanding the mechanisms of these diseases and may offer potential therapeutic targets.

References:

1. Ménager, Mickaël M. . TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells. In Biochemical Society transactions, 45, 703-708. doi:10.1042/BST20160439. https://pubmed.ncbi.nlm.nih.gov/28620031/

2. Chen, Long, Liu, Hongwei, Li, Yanwen, Wanggou, Siyi, Li, Xuejun. 2023. Functional characterization of TSPAN7 as a novel indicator for immunotherapy in glioma. In Frontiers in immunology, 14, 1105489. doi:10.3389/fimmu.2023.1105489. https://pubmed.ncbi.nlm.nih.gov/36845098/

3. Yu, Xi, Li, Shenglan, Pang, Mingrui, Wang, Lei, Liu, Xiuheng. 2021. TSPAN7 Exerts Anti-Tumor Effects in Bladder Cancer Through the PTEN/PI3K/AKT Pathway. In Frontiers in oncology, 10, 613869. doi:10.3389/fonc.2020.613869. https://pubmed.ncbi.nlm.nih.gov/33489923/

4. Lu, Bingnan, Liu, Yifan, Yao, Yuntao, Pan, Xiuwu, Cui, Xingang. 2024. Unveiling the unique role of TSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis. In Biology direct, 19, 72. doi:10.1186/s13062-024-00516-8. https://pubmed.ncbi.nlm.nih.gov/39175035/

5. Jiang, Dong, Jiang, Zheng, Lu, Di, Meng, Anming, Yu, Li. 2019. Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. In Nature cell biology, 21, 966-977. doi:10.1038/s41556-019-0358-6. https://pubmed.ncbi.nlm.nih.gov/31371827/

6. Wang, Xianguo, Lin, Min, Zhao, Jinping, Xu, Ming, Zhou, Xuefeng. 2018. TSPAN7 promotes the migration and proliferation of lung cancer cells via epithelial-to-mesenchymal transition. In OncoTargets and therapy, 11, 8815-8822. doi:10.2147/OTT.S167902. https://pubmed.ncbi.nlm.nih.gov/30588007/

7. Pang, Shuo, Luo, Zhuohui, Dong, Wei, Zhang, Li, Zhang, Lianfeng. 2022. Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats. In Life science alliance, 6, . doi:10.26508/lsa.202201616. https://pubmed.ncbi.nlm.nih.gov/36625203/

8. Perot, Brieuc P, García-Paredes, Victor, Luka, Marine, Ménager, Mickaël M. 2020. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4+ T Lymphocytes. In Frontiers in cellular and infection microbiology, 10, 70. doi:10.3389/fcimb.2020.00070. https://pubmed.ncbi.nlm.nih.gov/32181159/

9. Huang, Runzhi, Sun, Hanlin, Lin, Ruoyi, Meng, Tong, Huang, Zongqiang. 2022. The role of tetraspanins pan-cancer. In iScience, 25, 104777. doi:10.1016/j.isci.2022.104777. https://pubmed.ncbi.nlm.nih.gov/35992081/

10. Bassani, Silvia, Passafaro, Maria. . TSPAN7: A new player in excitatory synapse maturation and function. In Bioarchitecture, 2, 95-97. doi:. https://pubmed.ncbi.nlm.nih.gov/22880149/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest