C57BL/6NCya-Trpc1em1/Cya
Common Name
Trpc1-KO
Product ID
S-KO-05569
Backgroud
C57BL/6NCya
Strain ID
KOCMP-22063-Trpc1-B6N-VA
When using this mouse strain in a publication, please cite “Trpc1-KO Mouse (Catalog S-KO-05569) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Trpc1-KO
Strain ID
KOCMP-22063-Trpc1-B6N-VA
Gene Name
Product ID
S-KO-05569
Gene Alias
Trp1, Mtrp1, Trrp1
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000189137
NCBI RefSeq
NM_011643
Target Region
Exon 2~3
Size of Effective Region
~6.5 kb
Overview of Gene Research
Trpc1, encoding a non-selective cation channel, is the first mammalian Trp channel cloned [1]. It functions as a key component in pathways controlling Ca(2+) entry in response to cell-surface receptor activation, affecting basic cell functions like proliferation, survival, and cell-type specific functions such as neuronal growth cone chemotropic turning [1]. It is involved in store-operated Ca(2+) entry (SOCE) pathways, and its dysregulation may contribute to various diseases [3,4]. Genetically engineered mice with Trpc1 ablation have been crucial for studying its role [1].
In these mouse models, although they can reach adulthood, they exhibit defects in multiple organs and tissues including the cardiovascular, central nervous, skeletal and muscular, and immune systems [1]. Genetic and functional studies using these models have implicated Trpc1 in diseases such as diabetic nephropathy, Parkinson's disease, Huntington's disease, Duchenne muscular dystrophy, cancer, seizures, and Darier-White skin disease [1]. In colon cancer cells, inhibiting Trpc1 expression with tools like difluoromethylornithine (DFMO) eliminates its contribution to SOCE, abolishing cancer hallmarks [2].
In conclusion, Trpc1 plays essential roles in maintaining normal cell functions and Ca(2+) homeostasis through its involvement in SOCE. Studies on Trpc1-KO mouse models have revealed its significance in various disease conditions, such as neurodegenerative diseases, muscular dystrophy, and cancer, providing valuable insights into disease mechanisms and potential therapeutic targets.
References:
1. Nesin, Vasyl, Tsiokas, Leonidas. . TRPC1. In Handbook of experimental pharmacology, 222, 15-51. doi:10.1007/978-3-642-54215-2_2. https://pubmed.ncbi.nlm.nih.gov/24756701/
2. Villalobos, Carlos, Hernández-Morales, Miriam, Gutiérrez, Lucía G, Núñez, Lucía. 2019. TRPC1 and ORAI1 channels in colon cancer. In Cell calcium, 81, 59-66. doi:10.1016/j.ceca.2019.06.003. https://pubmed.ncbi.nlm.nih.gov/31203007/
3. Ambudkar, Indu S, de Souza, Lorena Brito, Ong, Hwei Ling. 2016. TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces. In Cell calcium, 63, 33-39. doi:10.1016/j.ceca.2016.12.009. https://pubmed.ncbi.nlm.nih.gov/28089266/
4. Elzamzamy, Osama M, Penner, Reinhold, Hazlehurst, Lori A. 2020. The Role of TRPC1 in Modulating Cancer Progression. In Cells, 9, . doi:10.3390/cells9020388. https://pubmed.ncbi.nlm.nih.gov/32046188/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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