Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Dcaf13em1/Cya
Common Name:
Dcaf13-KO
Product ID:
S-KO-05693
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Dcaf13-KO
Strain ID
KOCMP-223499-Dcaf13-B6J-VA
Gene Name
Dcaf13
Product ID
S-KO-05693
Gene Alias
Gm83; Wdsof1
Background
C57BL/6JCya
NCBI ID
223499
Modification
Conventional knockout
Chromosome
15
Phenotype
MGI:2684929
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dcaf13em1/Cya mice (Catalog S-KO-05693) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022909
NCBI RefSeq
NM_198606
Target Region
Exon 2~6
Size of Effective Region
~9.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
DCAF13, short for DDB1 and CUL4 associated factor 13, is a substrate receptor of the E3 ubiquitin ligase CRL4. It is involved in ubiquitination processes, which play crucial roles in regulating protein stability, function, and degradation, thus impacting various biological pathways and cellular functions [1,2,3,4]. Ubiquitination is essential for normal regulation of many biological functions such as cell cycle progression, DNA damage repair, and embryo development [4,5].

In disease-related research, DCAF13 has been found to be highly expressed in lung adenocarcinoma, ovarian cancer, and breast cancer, promoting cancer progression. In lung adenocarcinoma, it inhibits the p53 signaling pathway by promoting p53 ubiquitination and degradation, thus facilitating cancer cell proliferation and migration [1]. In ovarian cancer, it activates the FRAS1-mediated FAK signaling pathway by targeting FRAS1 for polyubiquitination and proteasomal degradation [2]. In breast cancer, it promotes cell proliferation by ubiquitin-inhibiting PERP expression [4]. Additionally, in preeclampsia, abnormal expression of DCAF13 affects endometrial decidualization, which may be involved in the occurrence and development of this pregnancy-related disorder [6]. In terms of embryo development, knockdown of DCAF13 in porcine embryos decreased blastocyst-stage development, affecting histone methylation-related gene expression and DNA damage repair [5]. In mice, uterine decidualization failed in pseudopregnant conditional Dcaf13 knockout mice, indicating its key role in decidualization [6]. Maternal-specific deletion of DCAF13 in mouse oocytes led to abnormal chromatin condensation and transcription in zygotic embryos, arresting development at the two-cell stage [7].

In summary, DCAF13 is essential for multiple biological processes, with its dysregulation contributing to various diseases. Gene knockout and conditional knockout mouse models have been pivotal in revealing its roles in cancer progression, embryo development, and preeclampsia, providing insights into potential therapeutic targets and disease mechanisms.

References:

1. Wei, Shan, Xing, Jing, Chen, Jia, Wang, Kai, Yu, Wanjun. 2024. DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma. In Journal of experimental & clinical cancer research : CR, 43, 3. doi:10.1186/s13046-023-02936-2. https://pubmed.ncbi.nlm.nih.gov/38163876/

2. Tang, Ze-Yi, Wang, Xiao-Min, Xu, Chun-Wei, Cheng, Shu-Qun, Pan, Wei-Wei. 2024. DCAF13 promotes ovarian cancer progression by activating FRAS1-mediated FAK signaling pathway. In Cellular and molecular life sciences : CMLS, 81, 421. doi:10.1007/s00018-024-05446-2. https://pubmed.ncbi.nlm.nih.gov/39367995/

3. Ren, Peipei, Tong, Xiaomei, Li, Junjian, Zhang, Songying, Zhang, Yin-Li. 2024. CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes. In Cellular and molecular life sciences : CMLS, 81, 165. doi:10.1007/s00018-024-05185-4. https://pubmed.ncbi.nlm.nih.gov/38578457/

4. Shan, Bao-Qian, Wang, Xiao-Min, Zheng, Li, Pan, Wei-Wei, Zhang, Xin. 2022. DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression. In Cancer science, 113, 1587-1600. doi:10.1111/cas.15300. https://pubmed.ncbi.nlm.nih.gov/35178836/

5. da Silva, Zigomar, Glanzner, Werner Giehl, Gutierrez, Karina, Gonçalves, Paulo Bayard Dias, Bordignon, Vilceu. 2023. DCAF13 and RNF114 participate in the regulation of early porcine embryo development. In Reproduction (Cambridge, England), 166, 401-410. doi:10.1530/REP-23-0230. https://pubmed.ncbi.nlm.nih.gov/37855431/

6. Yan, Xingyu, Rong, Miaomiao, Zhou, Qianhui, Zhang, Cong. 2022. DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization. In Molecular and cellular endocrinology, 556, 111741. doi:10.1016/j.mce.2022.111741. https://pubmed.ncbi.nlm.nih.gov/35932979/

7. Liu, Yang, Zhao, Long-Wen, Shen, Jing-Ling, Fan, Heng-Yu, Jin, Yan. 2019. Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development. In Scientific reports, 9, 6278. doi:10.1038/s41598-019-42179-w. https://pubmed.ncbi.nlm.nih.gov/31000741/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest