C57BL/6JCya-Vimem1/Cya
Common Name
Vim-KO
Product ID
S-KO-05697
Backgroud
C57BL/6JCya
Strain ID
KOCMP-22352-Vim-B6J-VA
When using this mouse strain in a publication, please cite “Vim-KO Mouse (Catalog S-KO-05697) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Vim-KO
Strain ID
KOCMP-22352-Vim-B6J-VA
Gene Name
Product ID
S-KO-05697
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000028062
NCBI RefSeq
NM_011701
Target Region
Exon 1
Size of Effective Region
~0.3 kb
Overview of Gene Research
Vim, encoding vimentin, is a gene that codes for a major cytoskeletal protein. Vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics, coordinating mechanosensing, transduction, signaling pathways, motility, and inflammatory responses [1].
Initial studies on the vimentin knockout (Vim-/- ) mouse indicated it could develop and reproduce without an obvious phenotype, but subsequent comprehensive analyses revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells. These often reflected altered responses in tissue recovery following various insults or injuries, supporting the idea that vimentin is essential in these processes [1].
In conclusion, Vim, through encoding vimentin, is crucial for cell mechanics and coordinating multiple cellular functions. The study of Vim-/- mouse models has significantly contributed to understanding its role in tissue recovery after insults, providing insights into potential mechanisms underlying various disease conditions related to tissue injury and repair.
References:
1. Ridge, Karen M, Eriksson, John E, Pekny, Milos, Goldman, Robert D. . Roles of vimentin in health and disease. In Genes & development, 36, 391-407. doi:10.1101/gad.349358.122. https://pubmed.ncbi.nlm.nih.gov/35487686/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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