C57BL/6JCya-Dzip3em1/Cya
Common Name:
Dzip3-KO
Product ID:
S-KO-05790
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Dzip3-KO
Strain ID
KOCMP-224170-Dzip3-B6J-VA
Gene Name
Product ID
S-KO-05790
Gene Alias
2310047C04Rik; 2A-HUB; 6430549P11Rik; A230104G20
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dzip3em1/Cya mice (Catalog S-KO-05790) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000121869
NCBI RefSeq
NM_001110017
Target Region
Exon 3~4
Size of Effective Region
~2.0 kb
Detailed Document
Overview of Gene Research
DZIP3, also known as DAZ-interacting zinc finger 3, is an RNA-binding RING-type ubiquitin ligase. It is involved in multiple biological processes, such as regulating chemokine-or estradiol-induced gene expression, self-renewal, and maintaining pluripotency in mouse embryonic stem cells [4]. It also affects the biological behavior of glioma through the angiogenesis pathway and may be involved in the mechanism of angiogenesis in glioma's invasive biological process [1].
In glioma, DZIP3 expression is related to the World Health Organization (WHO) grade, IDH1 status, and clinical outcome. Lower DZIP3 expression is seen in malignant cases, and it is an independent predictive factor of good prognosis in all grade and lower grade gliomas [1]. In gastric cancer, DZIP3 is significantly up-regulated, promotes proliferation and metastasis of cancer cells, and its higher expression is positively associated with poor prognosis [2]. In cancer cell models, DZIP3 promotes tumor growth and metastasis, and its depletion leads to reduced Cyclin D1 expression, G1 arrest, and defective cell growth [3].
In summary, DZIP3 is a key factor in multiple biological processes and disease conditions. Its role in promoting or inhibiting tumor-related processes in glioma and gastric cancer is significant, as revealed through various functional studies. The findings contribute to understanding the mechanisms of these diseases and may provide potential targets for therapy.
References:
1. Liang, Tingyu, Zhou, Xingang, Li, Peiliang, Wang, Peng, Feng, Enshan. 2020. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas. In Aging, 12, 24995-25004. doi:10.18632/aging.103817. https://pubmed.ncbi.nlm.nih.gov/33229627/
2. Qiu, Rongfang, Zhao, Siyu, Lu, Chenying, Yang, Yang, Ji, Jiansong. 2023. Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells. In Experimental cell research, 425, 113525. doi:10.1016/j.yexcr.2023.113525. https://pubmed.ncbi.nlm.nih.gov/36841324/
3. Kolapalli, Srinivasa P, Sahu, Rinku, Chauhan, Nishant R, Chauhan, Santosh, Chauhan, Swati. 2020. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. In Cancer research, 81, 315-331. doi:10.1158/0008-5472.CAN-20-1871. https://pubmed.ncbi.nlm.nih.gov/33067265/
4. Oikawa, Daisuke, Shiota, Masayuki, Tokunaga, Fuminori, Wanibuchi, Hideki. 2018. Generation of Rat Monoclonal Antibodies Specific for DZIP3. In Monoclonal antibodies in immunodiagnosis and immunotherapy, 37, 153-157. doi:10.1089/mab.2018.0005. https://pubmed.ncbi.nlm.nih.gov/29812999/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen