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C57BL/6JCya-Gm94em1/Cya
Common Name:
Gm94-KO
Product ID:
S-KO-05879
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Gm94-KO
Strain ID
KOCMP-225443-Gm94-B6J-VA
Gene Name
Gm94
Product ID
S-KO-05879
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
225443
Modification
Conventional knockout
Chromosome
18
Phenotype
MGI:2684940
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gm94em1/Cya mice (Catalog S-KO-05879) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000096570
NCBI RefSeq
NM_001033280
Target Region
Exon 2
Size of Effective Region
~0.2 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Gm94 is encoded by the mouse C5orf46 homologous gene. Its human counterpart, AP-64 encoded by C5orf46, is an antimicrobial peptide (AMP) contributing to the innate immune response, protecting against microbes on skin and mucosal surfaces. Thus, Gm94 likely plays a role in the innate immune defense pathway against microbial invasion [1].

The study found that Gm94 closely resembles AP-64 in its antibacterial properties. AP-64 exhibited significant antibacterial activity against Gram-negative bacteria like Escherichia coli DH5α, Escherichia coli O157:H7, Vibrio cholerae, and Pseudomonas aeruginosa, and was efficient in combating Escherichia coli O157:H7 infections in a mouse model. This indicates that Gm94 may have similar antibacterial functions in mouse models, suggesting its importance in innate immune-related antibacterial defense [1].

In conclusion, Gm94, through its resemblance to AP-64, likely plays an essential role in the innate immune system's antibacterial defense. Mouse models, by demonstrating the antibacterial properties similar to those of the human-derived peptide, help in understanding the role of Gm94 in antibacterial innate immune responses [1].

References:

1. Zhong, Kunhong, Wang, Yuelong, Wang, Zeng, Yang, Hui, Tong, Aiping. 2021. AP-64, Encoded by C5orf46, Exhibits Antimicrobial Activity against Gram-Negative Bacteria. In Biomolecules, 11, . doi:10.3390/biom11040485. https://pubmed.ncbi.nlm.nih.gov/33804835/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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