Gstp3, glutathione S-transferase pi 3, is likely involved in glutathione-related metabolism pathways. Glutathione is crucial for cellular oxidative stress response and lipid peroxidation inactivation. Proteins related to glutathione metabolism may interact with Gstp3, and its function is significant for maintaining normal cellular metabolism and potentially for protecting cells from oxidative damage [2].

In one study, maternal Di-(2-ethylhexyl)-phthalate (DEHP) exposure during pregnancy was found to induce mutations in Gstp3 in offspring mice. This led to liver cell damage and affected host metabolism, increasing the risk of metabolic disorders in immature offspring [1].

In conclusion, Gstp3 plays a role in metabolism-related biological functions. The discovery from the DEHP-exposed mouse model reveals its importance in preventing metabolic disorders, suggesting that disruptions in Gstp3 function may be associated with the development of such disorders [1].

References:

1. Huang, Binbin, Zhang, Na, Wang, Juan, Jiang, Minmin, Han, Maozhen. 2024. Maternal Di-(2-ethylhexyl)-Phthalate exposure during pregnancy altered energy metabolism in immature offspring and caused hyperglycemia. In Ecotoxicology and environmental safety, 279, 116494. doi:10.1016/j.ecoenv.2024.116494. https://pubmed.ncbi.nlm.nih.gov/38820878/

2. Bidooki, Seyed Hesamoddin, Sánchez-Marco, Javier, Martínez-Beamonte, Roberto, Rodríguez-Yoldi, María J, Osada, Jesús. 2023. Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line. In International journal of molecular sciences, 24, . doi:10.3390/ijms242417131. https://pubmed.ncbi.nlm.nih.gov/38138960/