C57BL/6JCya-Gstp3em1/Cya
Common Name
Gstp3-KO
Product ID
S-KO-05906
Backgroud
C57BL/6JCya
Strain ID
KOCMP-225884-Gstp3-B6J-VA
Status
When using this mouse strain in a publication, please cite “Gstp3-KO Mouse (Catalog S-KO-05906) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Gstp3-KO
Strain ID
KOCMP-225884-Gstp3-B6J-VA
Gene Name
Product ID
S-KO-05906
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000189808
NCBI RefSeq
NM_144869
Target Region
Exon 1~7
Size of Effective Region
~9.8 kb
Overview of Gene Research
Gstp3, glutathione S-transferase pi 3, is likely involved in glutathione-related metabolism pathways. Glutathione is crucial for cellular oxidative stress response and lipid peroxidation inactivation. Proteins related to glutathione metabolism may interact with Gstp3, and its function is significant for maintaining normal cellular metabolism and potentially for protecting cells from oxidative damage [2].
In one study, maternal Di-(2-ethylhexyl)-phthalate (DEHP) exposure during pregnancy was found to induce mutations in Gstp3 in offspring mice. This led to liver cell damage and affected host metabolism, increasing the risk of metabolic disorders in immature offspring [1].
In conclusion, Gstp3 plays a role in metabolism-related biological functions. The discovery from the DEHP-exposed mouse model reveals its importance in preventing metabolic disorders, suggesting that disruptions in Gstp3 function may be associated with the development of such disorders [1].
References:
1. Huang, Binbin, Zhang, Na, Wang, Juan, Jiang, Minmin, Han, Maozhen. 2024. Maternal Di-(2-ethylhexyl)-Phthalate exposure during pregnancy altered energy metabolism in immature offspring and caused hyperglycemia. In Ecotoxicology and environmental safety, 279, 116494. doi:10.1016/j.ecoenv.2024.116494. https://pubmed.ncbi.nlm.nih.gov/38820878/
2. Bidooki, Seyed Hesamoddin, Sánchez-Marco, Javier, Martínez-Beamonte, Roberto, Rodríguez-Yoldi, María J, Osada, Jesús. 2023. Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line. In International journal of molecular sciences, 24, . doi:10.3390/ijms242417131. https://pubmed.ncbi.nlm.nih.gov/38138960/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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