C57BL/6NCya-Oosp2em1/Cya
Common Name:
Oosp2-KO
Product ID:
S-KO-05917
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Oosp2-KO
Strain ID
KOCMP-225922-Oosp2-B6N-VA
Gene Name
Product ID
S-KO-05917
Gene Alias
Gm99; Plac1l; Tmem122
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Oosp2em1/Cya mice (Catalog S-KO-05917) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000121793
NCBI RefSeq
NM_001037634
Target Region
Exon 2~3
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Oosp2 is a member of the Oosp family genes. While its specific aliases are not provided in the given references, it has been linked to the female reproductive system. In human oocyte maturation, it has been found to play a functional role. Oosp2 inducing factor can trigger specific signaling pathways, such as those involving small GTPases, through translational regulation during human oocyte maturation [1].
Nuclease technology-mediated knockout of three Oosp family genes (including Oosp2) in mice led to decreased prolificacy but not infertility. This indicates that Oosp2 may be dispensable for female fertility in mice [2].
In summary, Oosp2 appears to have a role in human oocyte maturation, potentially through translational regulation of signaling pathways. In mouse models, gene knockout of Oosp2 as part of a triple-knockout of Oosp family genes suggests its dispensability for female fertility. These findings contribute to our understanding of the molecular mechanisms underlying female reproduction and may have implications for fertility-related research.
References:
1. Hu, Wenqi, Zeng, Haitao, Shi, Yanan, Liang, Xiaoyan, Kee, Kehkooi. 2022. Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. In Nature communications, 13, 5114. doi:10.1038/s41467-022-32791-2. https://pubmed.ncbi.nlm.nih.gov/36042231/
2. Abbasi, Ferheen, Kodani, Mayo, Emori, Chihiro, Fujihara, Yoshitaka, Ikawa, Masahito. 2020. Nuclease technology-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice. In Cells, 9, . doi:10.3390/cells9040821. https://pubmed.ncbi.nlm.nih.gov/32231122/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen