C57BL/6NCya-Zfp27em1/Cya
Common Name:
Zfp27-KO
Product ID:
S-KO-06031
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Zfp27-KO
Strain ID
KOCMP-22689-Zfp27-B6N-VA
Gene Name
Product ID
S-KO-06031
Gene Alias
Zfp-27; mkr-4; mszf76
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Zfp27em1/Cya mice (Catalog S-KO-06031) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000162592
NCBI RefSeq
NM_001285797
Target Region
Exon 4~5
Size of Effective Region
~4.8 kb
Detailed Document
Overview of Gene Research
Zfp27, zinc finger protein 27, is a transcription factor that appears to be involved in regulating autophagy pathways, an important cellular process related to the degradation and recycling of cellular components [1]. Autophagy has implications in maintaining cellular homeostasis and is associated with various biological processes and disease states.
In Parkinson's disease (PD) mouse models, iron deposition was found to inhibit insulin-like growth factor 2 (IGF2) and Zfp27 [1]. Knockdown of Zfp27 reduced LC3-induced autophagy flux, and Zfp27 affected autophagy by regulating LC3 promoter activity [1]. These results suggest that iron-mediated inhibition of Zfp27 leads to reduced autophagy, ultimately decreasing dopamine neurons and accelerating PD progression [1].
In conclusion, Zfp27 is a key factor in the autophagy pathway that is significantly influenced by iron deposition in the context of Parkinson's disease. The study of Zfp27 using PD mouse models has provided insights into the molecular mechanisms underlying PD, emphasizing its role in autophagy-related PD progression.
References:
1. Wang, Yinying, Wen, Qian, Chen, Rongsha, Yang, Zhongshan, Yan, Jinyuan. 2023. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. In Journal of cellular and molecular medicine, 27, 3614-3627. doi:10.1111/jcmm.17946. https://pubmed.ncbi.nlm.nih.gov/37668106/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen