Tnks1bp1, originally identified as an interaction protein of tankyrase 1, belongs to the poly(ADP-ribose) polymerase (PARP) superfamily. It is involved in multiple biological processes. In DNA repair, it participates in the DNA double-strand break repair machinery. It also has a role in regulating the actin cytoskeleton and is associated with pathways related to cell invasion and autophagy, thus being of great importance in cancer-related biological events [3,4].

In hepatocellular carcinoma (HCC), knocking down Tnks1bp1 synergizes with anti-PD-L1 treatment. Tnks1bp1 interacts with TRIM21 to mediate the ubiquitination of CNOT4, promoting HCC progression and immune evasion. In radiation-induced lung injury, Tnks1bp1 knockout (KO) mice demonstrate prevention of IR-induced lung tissue senescence and injury as Tnks1bp1 up-regulation causes AECII senescence [1,2].

In conclusion, Tnks1bp1 is crucial in DNA repair, cell invasion, autophagy, and senescence processes. The use of Tnks1bp1 KO mouse models has revealed its role in HCC and radiation-induced lung injury, providing potential therapeutic targets for these diseases.

References:

1. Wang, Yuan, Sandrine, Ineza Karambizi, Ma, Li, Liu, Bo, Yuan, Xianglin. 2024. TNKS1BP1 facilitates ubiquitination of CNOT4 by TRIM21 to promote hepatocellular carcinoma progression and immune evasion. In Cell death & disease, 15, 511. doi:10.1038/s41419-024-06897-y. https://pubmed.ncbi.nlm.nih.gov/39019859/

2. Zhu, Jiaojiao, Ao, Xingkun, Liu, Yuhao, Zhou, Ping-Kun, Gu, Yongqing. 2024. TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation. In Respiratory research, 25, 299. doi:10.1186/s12931-024-02914-y. https://pubmed.ncbi.nlm.nih.gov/39113018/

3. Zou, Lian-Hong, Shang, Zeng-Fu, Tan, Wei, Zhong, Cai-Gao, Zhou, Ping-Kun. . TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. In Oncotarget, 6, 7011-22. doi:. https://pubmed.ncbi.nlm.nih.gov/25749521/

4. Ohishi, Tomokazu, Yoshida, Haruka, Katori, Masamichi, Natsume, Tohru, Seimiya, Hiroyuki. 2017. Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion. In Cancer research, 77, 2328-2338. doi:10.1158/0008-5472.CAN-16-1846. https://pubmed.ncbi.nlm.nih.gov/28202517/