C57BL/6JCya-Klrb1fem1/Cya
Common Name
Klrb1f-KO
Product ID
S-KO-06530
Backgroud
C57BL/6JCya
Strain ID
KOCMP-232408-Klrb1f-B6J-VA
When using this mouse strain in a publication, please cite “Klrb1f-KO Mouse (Catalog S-KO-06530) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Klrb1f-KO
Strain ID
KOCMP-232408-Klrb1f-B6J-VA
Gene Name
Product ID
S-KO-06530
Gene Alias
Nkrp1f, Nkr-p1f, Nkrp1-f, A630024B12Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000032257
NCBI RefSeq
NM_153094
Target Region
Exon 2~5
Size of Effective Region
~3.4 kb
Overview of Gene Research
Klrb1f is a gene encoding one of the NK cell receptors. Natural killer (NK) cells are crucial in the immune response, and Klrb1f likely plays a role in the functions of these cells, though specific pathways and its exact function remain to be fully elucidated. Genetic models, such as mouse models, can be valuable tools in studying Klrb1f [1,2].
In the context of blood-stage malaria of Plasmodium chabaudi, vaccination affects the expression of Klrb1f. Blood-stage malaria induces the expression of Klrb1f in the liver, and vaccination enhances this malaria-induced expression. The interaction between KLRB1F (the protein encoded by Klrb1f) and its potential ligand CLEC2I between NK cells and erythroid cells facilitates extramedullary erythroblastosis in the liver. This interaction critically contributes to vaccination-induced survival from otherwise lethal blood-stage malaria [1]. In addition, in regulatory and helper T cells, analysis of expression Quantitative Trait Loci (eQTLs) suggested possible candidate genes that may regulate the expression of Klrb1f [2].
In conclusion, Klrb1f is involved in the immune-related processes, especially in the context of malaria and T cell regulation. Studies on Klrb1f using genetic models have revealed its significance in vaccination-mediated survival against malaria and in the regulatory mechanisms of T cells, providing insights into disease-related immune responses.
References:
1. Araúzo-Bravo, Marcos J, Delic, Denis, Gerovska, Daniela, Wunderlich, Frank. 2020. Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells. In Vaccines, 8, . doi:10.3390/vaccines8040677. https://pubmed.ncbi.nlm.nih.gov/33202767/
2. Alberts, Rudi, Chen, Hairong, Pommerenke, Claudia, Bruder, Dunja, Schughart, Klaus. 2011. Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. In BMC genomics, 12, 610. doi:10.1186/1471-2164-12-610. https://pubmed.ncbi.nlm.nih.gov/22182475/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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