C57BL/6JCya-Blvrbem1/Cya
Common Name
Blvrb-KO
Product ID
S-KO-06591
Backgroud
C57BL/6JCya
Strain ID
KOCMP-233016-Blvrb-B6J-VA
When using this mouse strain in a publication, please cite “Blvrb-KO Mouse (Catalog S-KO-06591) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Blvrb-KO
Strain ID
KOCMP-233016-Blvrb-B6J-VA
Gene Name
Product ID
S-KO-06591
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 7
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000037399
NCBI RefSeq
NM_144923
Target Region
Exon 2~5
Size of Effective Region
~7.8 kb
Overview of Gene Research
Blvrb, also known as biliverdin reductase B, is an NAD(P)H-dependent enzyme that catalyzes the reduction of biliverdin to bilirubin, playing a crucial role in maintaining cellular redox status. It is involved in redox-regulated pathways, such as those related to hematopoietic cell fate determination and the tumor necrosis factor stress pathway [1,3]. Genetic models, like mouse models, have been valuable in studying its functions.
In Blvrb-deficient mice, steady-state hematopoiesis is not affected, but an important cytoprotective function in stress hematopoiesis is revealed. There is a dichotomous megakaryocyte-biased hematopoietic recovery, with defective stress erythropoiesis in spleens and bone marrow erythroid development, accompanied by defective lipid peroxidation [1]. In humans, a loss-of-function mutation (BLVRB(S111L)) is causally associated with enhanced platelet production, highlighting its role in thrombopoiesis [2].
In conclusion, Blvrb is essential for redox-regulated hematopoietic cell fate, especially in megakaryocyte and erythroid development, as well as in stress hematopoiesis. Mouse models, particularly Blvrb-deficient mice, have provided key insights into its role in stress-related hematopoietic processes, and human studies suggest its importance in thrombopoiesis-related disorders [1,2].
References:
1. Nesbitt, Natasha M, Malone, Lisa E, Liu, Zhaoyan, Zhu, Wei, Bahou, Wadie F. 2020. Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis. In Free radical biology & medicine, 164, 164-174. doi:10.1016/j.freeradbiomed.2020.12.015. https://pubmed.ncbi.nlm.nih.gov/33359909/
2. Wu, Song, Li, Zongdong, Gnatenko, Dmitri V, Nesbitt, Natasha M, Bahou, Wadie F. 2016. BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans. In Blood, 128, 699-709. doi:10.1182/blood-2016-02-696997. https://pubmed.ncbi.nlm.nih.gov/27207795/
3. Bahou, Wadie F, Marchenko, Natalia, Nesbitt, Natasha M. 2023. Metabolic Functions of Biliverdin IXβ Reductase in Redox-Regulated Hematopoietic Cell Fate. In Antioxidants (Basel, Switzerland), 12, . doi:10.3390/antiox12051058. https://pubmed.ncbi.nlm.nih.gov/37237924/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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