Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Tubgcp5em1/Cya
Common Name:
Tubgcp5-KO
Product ID:
S-KO-06624
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tubgcp5-KO
Strain ID
KOCMP-233276-Tubgcp5-B6J-VA
Gene Name
Tubgcp5
Product ID
S-KO-06624
Gene Alias
B130010C12Rik; GCP5; mKIAA1899
Background
C57BL/6JCya
NCBI ID
233276
Modification
Conventional knockout
Chromosome
7
Phenotype
MGI:2178836
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tubgcp5em1/Cya mice (Catalog S-KO-06624) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000032627
NCBI RefSeq
NM_146190
Target Region
Exon 2~3
Size of Effective Region
~1.4 kb
Detailed Document
Click here to download >>
Overview of Gene Research
TUBGCP5, also known as tubulin gamma complex associated protein 5, is a paralog of TUBGCP4 and TUBGCP6. It is involved in centrosome formation, which is crucial for cell division and the maintenance of cell structure and function [3]. The gene is located in the 15q11.2 BP1-BP2 region, a locus associated with various neurodevelopmental disorders [3].

Individuals with the 15q11.2 BP1-BP2 microdeletion, which involves TUBGCP5 along with three other genes, may present with developmental and language delay, neurobehavioral disturbances, and psychiatric problems [1]. The TUBGCP5 gene is associated with attention-deficit hyperactivity disorder (ADHD) and compulsions, especially in Prader-Willi syndrome (PWS) patients with the larger 15q11-q13 Type I deletion [2]. A rare missense variant in TUBGCP5 was identified in a patient with primary microcephaly and mild developmental delay, suggesting its potential role in microcephaly [3]. In silico analyses showed that TUBGCP5 is associated with Prader-Willi syndrome among other neurodevelopmental disorders [4].

In conclusion, TUBGCP5 plays a significant role in centrosome formation and is implicated in multiple neurodevelopmental conditions such as ADHD, compulsions in PWS, and potentially microcephaly. Studies on TUBGCP5-related genetic variations, especially in the context of the 15q11.2 BP1-BP2 microdeletion, contribute to understanding the genetic mechanisms underlying these disorders.

References:

1. Cox, Devin M, Butler, Merlin G. 2015. The 15q11.2 BP1-BP2 microdeletion syndrome: a review. In International journal of molecular sciences, 16, 4068-82. doi:10.3390/ijms16024068. https://pubmed.ncbi.nlm.nih.gov/25689425/

2. Butler, Merlin G. 2023. Prader-Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review. In International journal of molecular sciences, 24, . doi:10.3390/ijms24054271. https://pubmed.ncbi.nlm.nih.gov/36901699/

3. Maver, Aleš, Čuturilo, Goran, Kovanda, Anja, Miletić, Aleksandra, Peterlin, Borut. 2018. Rare missense TUBGCP5 gene variant in a patient with primary microcephaly. In European journal of medical genetics, 62, 103598. doi:10.1016/j.ejmg.2018.12.003. https://pubmed.ncbi.nlm.nih.gov/30543990/

4. Rafi, Syed K, Butler, Merlin G. 2020. The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes. In International journal of molecular sciences, 21, . doi:10.3390/ijms21093296. https://pubmed.ncbi.nlm.nih.gov/32384786/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest