C57BL/6NCya-Cfap119em1/Cya
Common Name:
Cfap119-KO
Product ID:
S-KO-06669
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
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Basic Information
Strain Name
Cfap119-KO
Strain ID
KOCMP-233899-Cfap119-B6N-VA
Gene Name
Product ID
S-KO-06669
Gene Alias
Ccdc189; Gm166
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Cfap119em1/Cya mice (Catalog S-KO-06669) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000072155
NCBI RefSeq
NM_001033040
Target Region
Exon 4~8
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Cfap119, details about its key aliases and associated pathways are currently not provided in the given references. However, it is associated with male fertility, indicating its importance in reproductive biological processes [1,2].
Research on cheetahs, which have a long-term low effective population size, has identified Cfap119 as one of the genes with premature termination codons (PTCs) likely affecting gene function. Mutations within this gene, along with three other genes (DEFB116, ARL13A, and NT5DC4), are linked to sterility, including azoospermia which is common in cheetahs [2].
In conclusion, Cfap119 is essential for male fertility. Studies in cheetahs, a species with unique genetic characteristics due to population bottlenecks, have revealed that mutations in Cfap119 can lead to sterility, highlighting its significance in reproductive health. These findings contribute to understanding the genetic basis of fertility-related diseases and potentially offer insights for developing strategies to address such issues [1,2].
References:
1. Ghader, Aryan. 2025. Digest: Do weakly deleterious mutations exacerbate reproductive and health challenges in species with prolonged bottlenecks? In Evolution; international journal of organic evolution, , . doi:10.1093/evolut/qpaf046. https://pubmed.ncbi.nlm.nih.gov/40089805/
2. Peers, Jessica A, Nash, Will J, Haerty, Wilfried. . Gene pseudogenization in fertility-associated genes in cheetah (Acinonyx jubatus), a species with long-term low effective population size. In Evolution; international journal of organic evolution, 79, 574-585. doi:10.1093/evolut/qpaf005. https://pubmed.ncbi.nlm.nih.gov/39821281/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen