C57BL/6NCya-Cib3em1/Cya
Common Name
Cib3-KO
Product ID
S-KO-06716
Backgroud
C57BL/6NCya
Strain ID
KOCMP-234421-Cib3-B6N-VA
When using this mouse strain in a publication, please cite “Cib3-KO Mouse (Catalog S-KO-06716) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cib3-KO
Strain ID
KOCMP-234421-Cib3-B6N-VA
Gene Name
Product ID
S-KO-06716
Gene Alias
C730014M21Rik, Gm1107, KIP3
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 8
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000098630
NCBI RefSeq
NM_001080812
Target Region
Exon 2~3
Size of Effective Region
~3.4 kb
Overview of Gene Research
Cib3, a member of the calcium-and integrin-binding protein family, is involved in crucial biological functions, especially in the inner ear. It participates in the mechanoelectrical transduction (MET) pathway in hair cells, which is essential for hearing and balance perception. Genetic models, such as mouse models, are valuable for studying its function [1,2,3,4].
In mouse models, Cib3 can functionally substitute for Cib2 in cochlear hair cells. Loss-of-function studies show that Cib2 and Cib3 act redundantly to regulate MET in vestibular hair cells (VHCs). MET currents are completely abolished in VHCs of Cib2/Cib3 double-knock-out mice. Also, Cib2 and Cib3 have different roles in stereocilia maintenance in VHCs. Cib3 transcripts are highly expressed in the extrastriolar region, and its knockout mainly affects stereocilia maintenance in extrastriolar VHCs [1,2].
In conclusion, Cib3 is important for mechanoelectrical transduction and stereocilia maintenance in inner-ear hair cells. Studies using Cib3 knockout mouse models have revealed its role in balance-related functions, providing insights into the molecular mechanisms underlying hearing and balance disorders [1,2,4].
References:
1. Liang, Xiaoping, Qiu, Xufeng, Dionne, Gilman, Shapiro, Lawrence, Müller, Ulrich. 2021. CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. In Neuron, 109, 2131-2149.e15. doi:10.1016/j.neuron.2021.05.007. https://pubmed.ncbi.nlm.nih.gov/34089643/
2. Wang, Xiaoying, Liu, Shuang, Cheng, Qi, Xiong, Wei, Xu, Zhigang. 2023. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells. In The Journal of neuroscience : the official journal of the Society for Neuroscience, 43, 3219-3231. doi:10.1523/JNEUROSCI.1807-22.2023. https://pubmed.ncbi.nlm.nih.gov/37001993/
3. Giese, Arnaud P J, Weng, Wei-Hsiang, Kindt, Katie S, Sotomayor, Marcos, Ahmed, Zubair M. 2024. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.05.26.542533. https://pubmed.ncbi.nlm.nih.gov/37398045/
4. Wang, Xiaoying, Yi, Zhangyi, Shi, Mengwen, Sun, Yu. 2025. The Diverse Functions of the Calcium- and Integrin-Binding Protein Family. In International journal of molecular sciences, 26, . doi:10.3390/ijms26052223. https://pubmed.ncbi.nlm.nih.gov/40076845/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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