C57BL/6JCya-Mex3dem1/Cya
Common Name
Mex3d-KO
Product ID
S-KO-06893
Backgroud
C57BL/6JCya
Strain ID
KOCMP-237400-Mex3d-B6J-VA
When using this mouse strain in a publication, please cite “Mex3d-KO Mouse (Catalog S-KO-06893) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mex3d-KO
Strain ID
KOCMP-237400-Mex3d-B6J-VA
Gene Name
Product ID
S-KO-06893
Gene Alias
Rkhd1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000105350
NCBI RefSeq
NM_198615
Target Region
Exon 2
Size of Effective Region
~1.8 kb
Overview of Gene Research
MEX3D, a member of the MEX3 (muscle excess 3) family, is an RNA-binding protein. It has been implicated in post-transcriptional regulation of various biological processes [3]. However, its exact normal physiological function and associated pathways are not comprehensively detailed in the provided abstracts, but its role in disease has been more explored.
In prostate cancer, MEX3D is highly upregulated by loss of PTEN and/or expression of the TMPRSS2/ERG fusion gene. It drives soft agar colony formation, invasion, and tumor formation in vivo, and its oncogenic role is related to the induction of TCF3 [1]. In cervical carcinoma, MEX3D is upregulated by HPV16 E7 and promotes tumorigenesis by destabilizing TSC22D1 mRNA [2]. In non-small-cell lung cancer (NSCLC), overexpression of MEX3D is associated with significantly worse overall survival in patients with LUAD and LUSC [3].
In conclusion, MEX3D acts as an oncogenic driver in multiple cancers, such as prostate, cervical, and non-small-cell lung cancer. These findings from in vivo and in vitro studies in cancer models help to understand its role in tumorigenesis, suggesting that MEX3D could potentially be a therapeutic target for these cancers.
References:
1. Shao, Longjiang, Wang, Jianghua, Karatas, Omer, Ittmann, Michael. 2021. MEX3D is an oncogenic driver in prostate cancer. In The Prostate, 81, 1202-1213. doi:10.1002/pros.24216. https://pubmed.ncbi.nlm.nih.gov/34455614/
2. Zheng, Zhi, Chen, Xiaojing, Cai, Xiaoyun, Xu, Junfen, Cheng, Xiaodong. 2022. RNA-binding protein MEX3D promotes cervical carcinoma tumorigenesis by destabilizing TSC22D1 mRNA. In Cell death discovery, 8, 250. doi:10.1038/s41420-022-01049-7. https://pubmed.ncbi.nlm.nih.gov/35513372/
3. Zhang, Ming, Cao, Linfeng, Hou, Gouxin, Lv, Xiaodong, Deng, Jingjing. 2022. Investigation of the Potential Correlation Between RNA-Binding Proteins in the Evolutionarily Conserved MEX3 Family and Non-small-Cell Lung Cancer. In Molecular biotechnology, 65, 1263-1274. doi:10.1007/s12033-022-00638-2. https://pubmed.ncbi.nlm.nih.gov/36507941/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.