C57BL/6JCya-Ets1em1/Cya
Common Name:
Ets1-KO
Product ID:
S-KO-06998
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ets1-KO
Strain ID
KOCMP-23871-Ets1-B6J-VA
Gene Name
Product ID
S-KO-06998
Gene Alias
D230050P06; Ets-1; Tpl1; p54; vs
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ets1em1/Cya mice (Catalog S-KO-06998) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000034534
NCBI RefSeq
NM_011808
Target Region
Exon 7~8
Size of Effective Region
~2.3 kb
Detailed Document
Overview of Gene Research
Ets1, also known as E26 oncogene homolog 1, is a transcription factor belonging to the Ets family. It contains a unique DNA-binding domain, the Ets domain. Ets1 is involved in numerous biological processes such as cell differentiation, proliferation, apoptosis, migration, and tissue remodeling. It regulates gene expression in immune cells and other cell types, and is associated with pathways like Nrf2/HO-1, which is crucial for oxidative stress response [1,2].
In a hyperoxia-induced bronchopulmonary dysplasia (BPD) mouse model, Ets1 overexpression ameliorated BPD symptoms. It increased cell viability, glucose metabolism, and NADPH levels, while reducing inflammation, apoptosis, and ferroptosis-related markers in A549 cells and BPD mice. This effect was partially mediated by the Nrf2/HO-1 axis [1]. In Ets1 knockout mice, a lupus-like autoimmune disease developed, with enhanced activation and differentiation of B and T cells, indicating Ets1's role in maintaining immune cell quiescence [2].
In conclusion, Ets1 is a key transcription factor involved in multiple biological functions. Its study through gene knockout mouse models has revealed its importance in diseases such as BPD and autoimmune diseases. These models help in understanding the molecular mechanisms of Ets1-related diseases, providing potential directions for therapeutic interventions.
References:
1. Yang, Min, Chen, Yanping, Huang, Xueshan, Shen, Fang, Meng, Yanni. 2023. ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis. In Lung, 201, 425-441. doi:10.1007/s00408-023-00639-1. https://pubmed.ncbi.nlm.nih.gov/37490064/
2. Garrett-Sinha, Lee Ann. 2023. An update on the roles of transcription factor Ets1 in autoimmune diseases. In WIREs mechanisms of disease, 15, e1627. doi:10.1002/wsbm.1627. https://pubmed.ncbi.nlm.nih.gov/37565573/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen