C57BL/6JCya-Mgllem1/Cya
Common Name
Mgll-KO
Product ID
S-KO-07075
Backgroud
C57BL/6JCya
Strain ID
KOCMP-23945-Mgll-B6J-VA
When using this mouse strain in a publication, please cite “Mgll-KO Mouse (Catalog S-KO-07075) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mgll-KO
Strain ID
KOCMP-23945-Mgll-B6J-VA
Gene Name
Product ID
S-KO-07075
Gene Alias
Mgl, Magl
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000163271
NCBI RefSeq
NM_001166251
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Overview of Gene Research
Mgll, also known as monoglyceride lipase, is a key enzyme in lipid metabolism. It regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids [2]. It is involved in pathways related to lipid homeostasis and is associated with many biological processes and disease conditions. Gene knockout models of Mgll have been valuable for studying its functions.
In Mgll knockout mice (Mgll-/-), they exhibit elevated tissue levels of MAGs, along with resistance to the metabolic and cardiovascular perturbations induced by a high-fat diet (HFD). This indicates that Mgll is likely to be involved in diet-induced dysmetabolism [2]. Also, in pancreatic cancer, silencing Mgll in PANC-1 cells reduced cell proliferation, migration, and invasion, likely via the P-AKT/AKT pathway, suggesting Mgll promotes pancreatic cancer progression [3]. In endometrial adenocarcinoma, overexpression of Mgll promoted tumor proliferation, metastasis, and progesterone resistance, while knockdown inhibited these processes [1].
In conclusion, Mgll plays essential roles in lipid metabolism and is involved in disease processes such as diet-induced dysmetabolism, pancreatic cancer, and endometrial adenocarcinoma. The use of Mgll knockout mouse models has been crucial in revealing these roles, providing insights into the molecular mechanisms underlying these diseases and potential therapeutic targets.
References:
1. Ma, Xiaohong, Xia, Min, Wei, Lina, Qiu, Chunping, Jiang, Jie. 2022. ABX-1431 inhibits the development of endometrial adenocarcinoma and reverses progesterone resistance by targeting MGLL. In Cell death & disease, 13, 1067. doi:10.1038/s41419-022-05507-z. https://pubmed.ncbi.nlm.nih.gov/36550099/
2. Dione, Niokhor, Lacroix, Sébastien, Taschler, Ulrike, Di Marzo, Vincenzo, Silvestri, Cristoforo. 2020. Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota. In Cells, 9, . doi:10.3390/cells9122705. https://pubmed.ncbi.nlm.nih.gov/33348740/
3. Li, Weimin, Qian, Jin, Yang, Hanbo, He, Chenghai, Li, Guodong. . MGLL Promotes Pancreatic Cancer Progression and Invasion: Potential Therapeutic Inhibition by Melatonin. In Annals of clinical and laboratory science, 55, 10-18. doi:. https://pubmed.ncbi.nlm.nih.gov/40089287/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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