Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Cldn17em1/Cya
Common Name:
Cldn17-KO
Product ID:
S-KO-07135
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Cldn17-KO
Strain ID
KOCMP-239931-Cldn17-B6J-VA
Gene Name
Cldn17
Product ID
S-KO-07135
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
239931
Modification
Conventional knockout
Chromosome
16
Phenotype
MGI:2652030
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Cldn17em1/Cya mice (Catalog S-KO-07135) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000069549
NCBI RefSeq
NM_181490
Target Region
Exon 1
Size of Effective Region
~1.8 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Cldn17, a member of the claudin (CLDN) family, is a tight junction protein. As a paracellular channel-forming protein, it has an anion-selective channel function, and residues in its extracellular loops 1 and 2 are crucial for this function [4]. It is involved in maintaining blood-tissue barrier regulation, especially in the regulation of anion balance across these barriers [2,4].

In Cldn17 -/- mice, there are no breeding abnormalities, but newborn pups show delayed growth. Adult mice display electrolyte imbalance, oxidative stress, and kidney injury. RNA-sequencing reveals hyperactivation of signaling pathways and down-regulation of SOD1 expression in kidneys, indicating the importance of Cldn17 in maintaining electrolytes and reactive oxygen species across the blood-tissue barrier [2]. In oral cancer, down-regulation of Cldn17 is observed, and over-expressing it inhibits the invasion and migration of oral cancer cells by inhibiting epithelial-mesenchymal transition (EMT), suggesting it may act as a tumor suppressor [1]. In contrast, in hepatocellular carcinoma, increased Cldn17 expression promotes a malignant phenotype in hepatocytes via the Tyk2/Stat3 signaling pathway and is associated with poor prognosis [5]. In breast carcinomas, Cldn17 shows variable expression, and is significantly up-regulated at the mRNA level in tumors compared to normal breast tissue [6]. Also, in pancreatic adenocarcinoma, IgG-type autoantibodies against Cldn17, combined with CA19-9, may serve as non-invasive novel biomarkers for diagnosis [3,7].

In conclusion, Cldn17 plays essential roles in maintaining electrolyte balance and reactive oxygen species regulation in the body, especially in kidney function. Its dysregulation is associated with various cancers, such as oral, liver, breast, and pancreatic cancers. Studies using Cldn17 knockout mouse models have been instrumental in revealing its functions in physiological and pathological conditions, providing valuable insights into disease mechanisms and potential diagnostic and therapeutic targets.

References:

1. Xu, Ya-Ni, Deng, Ming-Si, Liu, Yun-Feng, Yao, Jun, Xiao, Zi-Yi. 2021. Tight junction protein CLDN17 serves as a tumor suppressor to reduce the invasion and migration of oral cancer cells by inhibiting epithelial-mesenchymal transition. In Archives of oral biology, 133, 105301. doi:10.1016/j.archoralbio.2021.105301. https://pubmed.ncbi.nlm.nih.gov/34781072/

2. Adil, Mir S, Parvathagiri, Varun, Verma, Arti, Narayanan, S Priya, Somanath, Payaningal R. 2022. Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress. In Cells, 11, . doi:10.3390/cells11111782. https://pubmed.ncbi.nlm.nih.gov/35681477/

3. Zhuang, Liping, Huang, Changjing, Ning, Zhouyu, Cheng, Chien-Shan, Meng, Zhiqiang. 2022. Circulating tumor-associated autoantibodies as novel diagnostic biomarkers in pancreatic adenocarcinoma. In International journal of cancer, 152, 1013-1024. doi:10.1002/ijc.34334. https://pubmed.ncbi.nlm.nih.gov/36274627/

4. Conrad, Marcel P, Piontek, Jörg, Günzel, Dorothee, Fromm, Michael, Krug, Susanne M. 2015. Molecular basis of claudin-17 anion selectivity. In Cellular and molecular life sciences : CMLS, 73, 185-200. doi:10.1007/s00018-015-1987-y. https://pubmed.ncbi.nlm.nih.gov/26194246/

5. Sun, Lemeng, Feng, Liangshu, Cui, Jiuwei. 2018. Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma. In Diagnostic pathology, 13, 72. doi:10.1186/s13000-018-0749-1. https://pubmed.ncbi.nlm.nih.gov/30219077/

6. Tőkés, Anna-Mária, Szász, Attila Marcell, Juhász, Eva, Salamon, Ferenc, Kulka, Janina. 2011. Expression of tight junction molecules in breast carcinomas analysed by array PCR and immunohistochemistry. In Pathology oncology research : POR, 18, 593-606. doi:10.1007/s12253-011-9481-9. https://pubmed.ncbi.nlm.nih.gov/22193974/

7. Liu, Yuqi, Gao, Yuyi, Wu, Yangxue, Wang, Keyan, Ye, Hua. . Autoantibodies as Potential Liquid Biopsy Biomarker in Detection of Pancreatic Cancer: A Diagnostic Test Accuracy Review and Meta-Analysis. In Scandinavian journal of immunology, 101, e70012. doi:10.1111/sji.70012. https://pubmed.ncbi.nlm.nih.gov/40185645/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest