C57BL/6NCya-Morc2bem1/Cya
Common Name:
Morc2b-KO
Product ID:
S-KO-07158
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Morc2b-KO
Strain ID
KOCMP-240069-Morc2b-B6N-VA
Gene Name
Product ID
S-KO-07158
Gene Alias
4932411A10Rik; Tce6
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
17
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Morc2bem1/Cya mice (Catalog S-KO-07158) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000053896
NCBI RefSeq
NM_177719
Target Region
Exon 2
Size of Effective Region
~3.1 kb
Detailed Document
Overview of Gene Research
Morc2b, a member of the microrchidia (MORC) family, is a germ cell-specific chromatin-remodelling factor. It has an essential role in meiotic progression and fertility, being involved in processes like chromosomal synapsis, meiotic recombination, and regulation of meiosis-specific gene expression [1]. Mouse models are valuable for studying its function.
Inactivation of Morc2b in KO mouse models leads to meiotic arrest and sterility in both male and female mice. Morc2b-deficient spermatocytes and oocytes show failures in chromosomal synapsis, blockades in meiotic recombination, and increased apoptosis. Also, loss of MORC2B causes mis-regulation of meiosis-specific genes. Additionally, MORC2B interacts with its sequence paralogue MORC2A [1]. In sterile mouse hybrids, down-regulated Morc2b is observed, along with failure to compartmentalize gammaH2AX into the pachynema sex (XY) body, defects similar to those in Prdm9-null mutants [2].
In conclusion, Morc2b is crucial for meiosis and fertility as revealed by mouse-based research. The gene knockout mouse models have shown its role in maintaining normal meiotic processes, and its dysregulation may be related to hybrid sterility, providing insights into the mechanisms underlying infertility and speciation [1,2].
References:
1. Shi, Baolu, Xue, Jiangyang, Zhou, Jian, Huang, Xiaoyan, Wang, P Jeremy. 2018. MORC2B is essential for meiotic progression and fertility. In PLoS genetics, 14, e1007175. doi:10.1371/journal.pgen.1007175. https://pubmed.ncbi.nlm.nih.gov/29329290/
2. Mihola, Ondrej, Trachtulec, Zdenek, Vlcek, Cestmir, Schimenti, John C, Forejt, Jiri. 2008. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. In Science (New York, N.Y.), 323, 373-5. doi:10.1126/science.1163601. https://pubmed.ncbi.nlm.nih.gov/19074312/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen