Scamp2, or Secretory Carrier-Associated Membrane Protein 2, is involved in vesicular transport and has a significant impact on multiple biological processes [5]. It participates in pathways related to exocytosis, which is crucial for the release of neurotransmitters and hormones. Additionally, it may play a role in regulating the cell surface expression of certain channels and transporters, thus influencing neuronal excitability and nutrient uptake [2,3]. Genetic models, such as KO/CKO mouse models, could potentially be valuable for further exploring its functions.

In acute myeloid leukemia (AML), the mRNA levels of Scamp2 are significantly higher in patients compared to healthy controls, and high Scamp2 mRNA expression is associated with poor overall survival. This might be due to its involvement in multiple tumor-related pathways [1]. In neurons, Scamp2 was identified as a novel Cav3.2-interacting protein, regulating the cell surface expression of T-type calcium channels and thus neuronal excitability [2]. In epithelial cells and neurons, it acts as an accessory protein for hSVCT1, regulating vitamin C transport, which is important for absorptive epithelia function and neurogenesis [3]. In PC12 cells, Scamp2 interacts with Arf6 and phospholipase D1, linking their function to exocytotic fusion pore formation [4]. It also affects the exocytosis in mast cells and PC12 cells through its E peptide-containing domain [6]. Moreover, Scamp2 interacts with the dopamine transporter (DAT) and serotonin transporter (SERT), regulating their subcellular distribution and function [7,8].

In conclusion, Scamp2 is essential for vesicular transport, exocytosis, and the regulation of cell surface proteins in various cell types. Its abnormal expression is associated with AML, highlighting its potential as a diagnostic and prognostic marker for this disease. Research on Scamp2 using genetic models could further elucidate its functions and its role in disease, providing insights for potential therapeutic strategies.

References:

1. Yue, Can, Xie, Siting, Zhong, Jiaying, Xu, Bing, Luo, Yiming. 2021. SCAMP2/5 as diagnostic and prognostic markers for acute myeloid leukemia. In Scientific reports, 11, 17012. doi:10.1038/s41598-021-96440-2. https://pubmed.ncbi.nlm.nih.gov/34426610/

2. Cmarko, Leos, Stringer, Robin N, Jurkovicova-Tarabova, Bohumila, Lacinova, Lubica, Weiss, Norbert. 2022. Secretory carrier-associated membrane protein 2 (SCAMP2) regulates cell surface expression of T-type calcium channels. In Molecular brain, 15, 1. doi:10.1186/s13041-021-00891-7. https://pubmed.ncbi.nlm.nih.gov/34980194/

3. Rashid, Mohammad A, Lin-Moshier, Yaping, Gunaratne, Gihan S, Marchant, Jonathan S, Subramanian, Veedamali S. 2023. Vitamin C transport in neurons and epithelia is regulated by secretory carrier-associated membrane protein-2 (SCAMP2). In International journal of biological macromolecules, 230, 123205. doi:10.1016/j.ijbiomac.2023.123205. https://pubmed.ncbi.nlm.nih.gov/36632962/

4. Liu, Lixia, Liao, Haini, Castle, Anna, Szabo, Gabor, Castle, David. 2005. SCAMP2 interacts with Arf6 and phospholipase D1 and links their function to exocytotic fusion pore formation in PC12 cells. In Molecular biology of the cell, 16, 4463-72. doi:. https://pubmed.ncbi.nlm.nih.gov/16030257/

5. Juszczak, Grzegorz R, Stankiewicz, Adrian M. 2017. Glucocorticoids, genes and brain function. In Progress in neuro-psychopharmacology & biological psychiatry, 82, 136-168. doi:10.1016/j.pnpbp.2017.11.020. https://pubmed.ncbi.nlm.nih.gov/29180230/

6. Liu, Lixia, Guo, Zhenheng, Tieu, Quyen, Castle, Anna, Castle, David. . Role of secretory carrier membrane protein SCAMP2 in granule exocytosis. In Molecular biology of the cell, 13, 4266-78. doi:. https://pubmed.ncbi.nlm.nih.gov/12475951/

7. Fjorback, Anja W, Müller, Heidi K, Haase, Jana, Raarup, Merete K, Wiborg, Ove. 2011. Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. In Biochemical and biophysical research communications, 406, 165-70. doi:10.1016/j.bbrc.2011.01.069. https://pubmed.ncbi.nlm.nih.gov/21295544/

8. Müller, Heidi Kaastrup, Wiborg, Ove, Haase, Jana. 2006. Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. In The Journal of biological chemistry, 281, 28901-9. doi:. https://pubmed.ncbi.nlm.nih.gov/16870614/