Gm4952 is a gene whose function, common aliases, associated pathways and overall biological importance are not comprehensively described in the provided abstract. However, it is known that its study could potentially be enhanced through genetic models such as gene knockout (KO) or conditional knockout (CKO) mouse models for in-vivo functional studies.

In a study on the effects of pre-conceptional glyphosate (GLY) exposure in mice [1], when dams were exposed to GLY (2mg/kg daily for 10 weeks starting at 7 weeks of age), at gestation day 14 (GD14), the hepatic protein abundance of Gm4952 was increased approximately 4-fold compared to the control group [1].

In conclusion, while the exact biological function of Gm4952 remains to be fully elucidated, the in-vivo study on mice exposed to glyphosate indicates that Gm4952 may be involved in the hepatic response to this environmental exposure. Further research using KO or CKO mouse models could potentially reveal more about its role in specific biological processes or disease-related conditions associated with such exposures. [1]

References:

1. Novbatova, Gulnara, Timme, Kelsey, Severin, Andrew, Sayadi, Maryam, Keating, Aileen F. . Pre-Conceptional Exposure to Glyphosate Affects the Maternal Hepatic and Ovarian Proteome. In Toxicological sciences : an official journal of the Society of Toxicology, 190, 204-214. doi:10.1093/toxsci/kfac098. https://pubmed.ncbi.nlm.nih.gov/36173347/