C57BL/6JCya-Slc5a2em1/Cya
Common Name:
Slc5a2-KO
Product ID:
S-KO-07665
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Slc5a2-KO
Strain ID
KOCMP-246787-Slc5a2-B6J-VA
Gene Name
Product ID
S-KO-07665
Gene Alias
Sglt2
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Slc5a2em1/Cya mice (Catalog S-KO-07665) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000118169
NCBI RefSeq
NM_133254.5
Target Region
Exon 4~5
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Slc5a2, also known as SGLT2, encodes the sodium-glucose cotransporter 2. This protein is crucial for glucose reuptake in the tubular system of the kidney, with SGLT2 responsible for the majority of this reabsorption, while SGLT1 (encoded by SLC5A1) reabsorbs the remainder [1]. Mutations in SLC5A2 are associated with glucosuria, highlighting its significance in maintaining normal glucose homeostasis [1]. Genetically modified mouse models can be valuable in further exploring its function and associated pathways [1].
Mutations in the SLC5A2 gene have been reported to cause familial renal glucosuria (FRG), a condition characterized by isolated glucosuria despite normal blood glucose levels. In Chinese families, several mutations in SLC5A2, including novel ones, have been identified in patients with FRG, such as c.1222G>T/p.(D408Y) and c.1496G>A/p.(R499H), suggesting a key role of SLC5A2 in the pathogenesis of FRG [2,3].
In conclusion, Slc5a2 is essential for renal glucose reabsorption, and its malfunction due to mutations can lead to conditions like familial renal glucosuria. The study of Slc5a2 using gene-modified mouse models can potentially provide more insights into the molecular mechanisms underlying glucose homeostasis and related diseases.
References:
1. Rieg, Timo, Vallon, Volker. 2018. Development of SGLT1 and SGLT2 inhibitors. In Diabetologia, 61, 2079-2086. doi:10.1007/s00125-018-4654-7. https://pubmed.ncbi.nlm.nih.gov/30132033/
2. Li, Shentang, Yang, Yeyi, Huang, Lihua, Kong, Min, Yang, Zuocheng. 2019. A novel compound heterozygous mutation in SLC5A2 contributes to familial renal glucosuria in a Chinese family, and a review of the relevant literature. In Molecular medicine reports, 19, 4364-4376. doi:10.3892/mmr.2019.10110. https://pubmed.ncbi.nlm.nih.gov/30942416/
3. Yu, Lei, Wu, Meng, Hou, Ping, Zhang, Hong. 2020. SLC5A2 mutations, including two novel mutations, responsible for renal glucosuria in Chinese families. In BMC nephrology, 21, 69. doi:10.1186/s12882-020-01725-9. https://pubmed.ncbi.nlm.nih.gov/32111189/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen