C57BL/6JCya-Or4d6em1/Cya
Common Name:
Or4d6-KO
Product ID:
S-KO-08090
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Or4d6-KO
Strain ID
KOCMP-258673-Or4d6-B6J-VA
Gene Name
Product ID
S-KO-08090
Gene Alias
MOR239-5; Olfr1428
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Or4d6em1/Cya mice (Catalog S-KO-08090) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000087824
NCBI RefSeq
NM_146678
Target Region
Exon 1
Size of Effective Region
~0.9 kb
Detailed Document
Overview of Gene Research
Or4d6, an olfactory receptor gene, is involved in the olfactory system which combines input from multiple receptor types to represent odor information. Olfactory receptors play a crucial role in the perception of various odors, and Or4d6 is part of this complex system that contributes to the overall understanding of olfactory coding [1].
A SNP (rs1453542) in Or4d6 was identified as a marker for gemcitabine/carboplatin-induced neutropenia, indicating its potential association with the response to chemotherapy drugs [2]. Also, Or4d6 was among 9 pathogenic germline variants clinically associated with survival outcome in rectal adenocarcinoma (READ), where patients carrying this germline susceptibility variant had an increased risk of poor survival [3]. Additionally, two linked SNPs in Or4d6 were associated with the musk Galaxolide, and it was the first human OR shown to drive specific anosmia to a musk compound [1].
In conclusion, Or4d6 is important for olfactory coding, specifically related to the perception of musk-like odors. It also has implications in chemotherapy-induced neutropenia and the survival outcome of rectal adenocarcinoma patients. Research on Or4d6 through genetic variants analysis provides insights into olfactory mechanisms and disease-related genetic factors, which may help in understanding disease processes and developing potential therapeutic strategies.
References:
1. Li, Bingjie, Kamarck, Marissa L, Peng, Qianqian, Mainland, Joel D, Wang, Sijia. 2022. From musk to body odor: Decoding olfaction through genetic variation. In PLoS genetics, 18, e1009564. doi:10.1371/journal.pgen.1009564. https://pubmed.ncbi.nlm.nih.gov/35113854/
2. Gréen, Henrik, Hasmats, Johanna, Kupershmidt, Ilya, Peterson, Curt, Lundeberg, Joakim. 2015. Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities. In Clinical cancer research : an official journal of the American Association for Cancer Research, 22, 366-73. doi:10.1158/1078-0432.CCR-15-0964. https://pubmed.ncbi.nlm.nih.gov/26378035/
3. Huang, Kevin Chih-Yang, Chiang, Shu-Fen, Ke, Tao-Wei, Chen, Tsung-Wei, Chao, Kun-San Clifford. . The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ). In Cancer genomics & proteomics, 17, 291-299. doi:10.21873/cgp.20189. https://pubmed.ncbi.nlm.nih.gov/32345670/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen