C57BL/6JCya-Or4d6em1/Cya
Common Name:
Or4d6-KO
Product ID:
S-KO-08090
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Or4d6-KO
Strain ID
KOCMP-258673-Or4d6-B6J-VA
Gene Name
Product ID
S-KO-08090
Gene Alias
MOR239-5; Olfr1428
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Or4d6em1/Cya mice (Catalog S-KO-08090) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000087824
NCBI RefSeq
NM_146678
Target Region
Exon 1
Size of Effective Region
~0.9 kb
Overview of Gene Research
Or4d6, an olfactory receptor gene, is involved in the olfactory system which combines input from multiple receptor types to represent odor information. Olfactory receptors play a crucial role in the perception of various odors, and Or4d6 is part of this complex system that contributes to the overall understanding of olfactory coding [1].
A SNP (rs1453542) in Or4d6 was identified as a marker for gemcitabine/carboplatin-induced neutropenia, indicating its potential association with the response to chemotherapy drugs [2]. Also, Or4d6 was among 9 pathogenic germline variants clinically associated with survival outcome in rectal adenocarcinoma (READ), where patients carrying this germline susceptibility variant had an increased risk of poor survival [3]. Additionally, two linked SNPs in Or4d6 were associated with the musk Galaxolide, and it was the first human OR shown to drive specific anosmia to a musk compound [1].
In conclusion, Or4d6 is important for olfactory coding, specifically related to the perception of musk-like odors. It also has implications in chemotherapy-induced neutropenia and the survival outcome of rectal adenocarcinoma patients. Research on Or4d6 through genetic variants analysis provides insights into olfactory mechanisms and disease-related genetic factors, which may help in understanding disease processes and developing potential therapeutic strategies.
References:
1. Li, Bingjie, Kamarck, Marissa L, Peng, Qianqian, Mainland, Joel D, Wang, Sijia. 2022. From musk to body odor: Decoding olfaction through genetic variation. In PLoS genetics, 18, e1009564. doi:10.1371/journal.pgen.1009564. https://pubmed.ncbi.nlm.nih.gov/35113854/
2. Gréen, Henrik, Hasmats, Johanna, Kupershmidt, Ilya, Peterson, Curt, Lundeberg, Joakim. 2015. Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities. In Clinical cancer research : an official journal of the American Association for Cancer Research, 22, 366-73. doi:10.1158/1078-0432.CCR-15-0964. https://pubmed.ncbi.nlm.nih.gov/26378035/
3. Huang, Kevin Chih-Yang, Chiang, Shu-Fen, Ke, Tao-Wei, Chen, Tsung-Wei, Chao, Kun-San Clifford. . The Clinical Relevance of Frequent Germline Genetic Variants Detected by Targeted Sequencing in Patients With Rectal Adenocarcinoma (READ). In Cancer genomics & proteomics, 17, 291-299. doi:10.21873/cgp.20189. https://pubmed.ncbi.nlm.nih.gov/32345670/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen