C57BL/6JCya-Or10p1em1/Cya
Common Name:
Or10p1-KO
Product ID:
S-KO-08283
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Or10p1-KO
Strain ID
KOCMP-258933-Or10p1-B6J-VA
Gene Name
Product ID
S-KO-08283
Gene Alias
MOR269-1; Olfr796
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Or10p1em1/Cya mice (Catalog S-KO-08283) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000037071
NCBI RefSeq
NM_146931
Target Region
Exon 1
Size of Effective Region
~1.3 kb
Detailed Document
Overview of Gene Research
Or10p1, also known as olfactory receptor family10 subfamily-p-member1, is involved in multiple physiological processes. It functions as the receptor for famsin in humans (equivalent to OLFR796 in mice), and is associated with the regulation of glucose homeostasis through the famsin-glucagon axis. Additionally, it may play a role in the heart rate response to β-blockers [1,2].
In glucose homeostasis, famsin binds to Or10p1 in islet α cells, initiating calcium release from the endoplasmic reticulum. This triggers glucagon secretion, which promotes hepatic glucose production. Deficiency of famsin signaling, thus affecting Or10p1-mediated function, reduces hepatic glucose production and lowers blood glucose levels, highlighting its significance in maintaining glucose balance [1]. Also, in a genome-wide association study, a SNP near Or10p1 was associated with the heart rate response to β-blockers, suggesting its role in cardiac rate regulation [2].
In conclusion, Or10p1 is essential in regulating glucose homeostasis through the famsin-glucagon axis and may have a role in the heart rate response to β-blockers. Research on Or10p1, especially through studies like the ones demonstrating its function in the famsin-glucagon pathway, helps to understand the underlying mechanisms of glucose-related disorders and potentially cardiac rate-related phenotypes.
References:
1. Long, Aijun, Wang, Yazhuo, Guo, Yihua, Wang, Jiqiu, Wang, Yiguo. 2024. A famsin-glucagon axis mediates glucose homeostasis. In Cell metabolism, 37, 629-639.e6. doi:10.1016/j.cmet.2024.11.008. https://pubmed.ncbi.nlm.nih.gov/39706194/
2. Shahin, Mohamed H, Conrado, Daniela J, Gonzalez, Daniel, Cooper-DeHoff, Rhonda M, Johnson, Julie A. 2018. Genome-Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β-Blockers. In Journal of the American Heart Association, 7, . doi:10.1161/JAHA.117.006463. https://pubmed.ncbi.nlm.nih.gov/29478026/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen