C57BL/6JCya-Slc7a11em1/Cya
Common Name
Slc7a11-KO
Product ID
S-KO-08541
Backgroud
C57BL/6JCya
Strain ID
KOCMP-26570-Slc7a11-B6J-VA
When using this mouse strain in a publication, please cite “Slc7a11-KO Mouse (Catalog S-KO-08541) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Slc7a11-KO
Strain ID
KOCMP-26570-Slc7a11-B6J-VA
Gene Name
Product ID
S-KO-08541
Gene Alias
9930009M05Rik, sut, xCT
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000029297
NCBI RefSeq
NM_011990
Target Region
Exon 3
Size of Effective Region
~0.1 kb
Overview of Gene Research
Slc7a11, also commonly known as xCT, is a key component of the cystine/glutamate antiporter system Xc-. It imports cystine for glutathione biosynthesis and antioxidant defense, playing a crucial role in cellular redox homeostasis and regulating processes like ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation [1,3].
In HCC, hepatocyte-specific ATF4-deficient MUP-uPA mice showed increased susceptibility to ferroptosis and accelerated HCC development due to decreased Slc7a11 expression. Re-expressing Slc7a11 reversed ferroptosis susceptibility and hepatocarcinogenesis, indicating its protective role in normal hepatocytes against stress-related ferroptosis [2]. In breast cancer, metformin induced ferroptosis by inhibiting the UFMylation of Slc7a11, reducing its protein stability and thus suppressing tumor growth [4].
In summary, Slc7a11 is essential for maintaining cellular redox balance and protecting cells from ferroptosis. Studies using gene-knockout mouse models in HCC and breast cancer have revealed its significant roles in these disease contexts, highlighting its potential as a therapeutic target for cancer treatment.
References:
1. Koppula, Pranavi, Zhuang, Li, Gan, Boyi. 2020. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. In Protein & cell, 12, 599-620. doi:10.1007/s13238-020-00789-5. https://pubmed.ncbi.nlm.nih.gov/33000412/
2. He, Feng, Zhang, Peng, Liu, Junlai, Yaden, Benjamin C, Karin, Michael. 2023. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. In Journal of hepatology, 79, 362-377. doi:10.1016/j.jhep.2023.03.016. https://pubmed.ncbi.nlm.nih.gov/36996941/
3. Lin, Wenyu, Wang, Chaoqun, Liu, Guangping, Zhou, Qiyin, Jin, Hongchuan. 2020. SLC7A11/xCT in cancer: biological functions and therapeutic implications. In American journal of cancer research, 10, 3106-3126. doi:. https://pubmed.ncbi.nlm.nih.gov/33163260/
4. Yang, Jingjing, Zhou, Yulu, Xie, Shuduo, Wang, Linbo, Zhou, Jichun. 2021. Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer. In Journal of experimental & clinical cancer research : CR, 40, 206. doi:10.1186/s13046-021-02012-7. https://pubmed.ncbi.nlm.nih.gov/34162423/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Publications
Cell Death Discovery
2024-10-01
Unveiling the crucial role of ferroptosis in host resistance to streptococcus agalactiae infection
Read More
Advanced Science
2022-11-28
Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1/L1 Response
Read More
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