C57BL/6NCya-Dusp13bem1/Cya
Common Name
Dusp13b-KO
Product ID
S-KO-08895
Backgroud
C57BL/6NCya
Strain ID
KOCMP-27389-Dusp13b-B6N-VA
When using this mouse strain in a publication, please cite “Dusp13b-KO Mouse (Catalog S-KO-08895) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Dusp13b-KO
Strain ID
KOCMP-27389-Dusp13b-B6N-VA
Gene Name
Product ID
S-KO-08895
Gene Alias
MDSP, TMDP, Dusp13, Gm1203, DUSP13A, TS-DSP6, LMW-DSP6
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000120956
NCBI RefSeq
NM_013849
Target Region
Exon 1~4
Size of Effective Region
~9.5 kb
Overview of Gene Research
Dusp13b, also known as TMDP, is an atypical dual-specificity phosphatase encoded by the DUSP13 gene. It inactivates stress-activated MAPKs in the order of selectivity JNK = p38>ERK in cells and suppresses AP-1-dependent gene expression, suggesting an important role in protecting spermatogenesis from external stress [1]. It has also been associated with other biological processes and disease-related pathways.
In NSCLC, itraconazole combined with osimertinib can inhibit the SHH/DUSP13B/p-STAT3 axis, reducing the proliferation and migration of osimertinib-resistant cells and promoting apoptosis. DUSP13B interacts with STAT3 and modulates its phosphorylation, and SHH, GLI1, p-STAT3, and DUSP13B play significant predictive roles in osimertinib resistance [2]. In cardiomyocytes, myogenin up-regulates DUSP13B, reducing apoptosis induced by reactive oxygen species through inactivating the p38 MAPK pathway [3].
In summary, Dusp13b is crucial in spermatogenesis protection, and its involvement in NSCLC drug resistance and cardiomyocyte apoptosis prevention reveals its importance in these biological and disease-related processes. Although no KO/CKO mouse model findings were presented, the studies suggest potential areas where such models could further clarify its functions and roles in diseases.
References:
1. Katagiri, Chiaki, Masuda, Kouhei, Nomura, Miyuki, Tanuma, Nobuhiro, Shima, Hiroshi. 2011. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. In Molecular and cellular biochemistry, 352, 155-62. doi:10.1007/s11010-011-0749-x. https://pubmed.ncbi.nlm.nih.gov/21360282/
2. Zheng, Hongmei, Tang, Yaoxiang, Zang, Hongjing, Ma, Jian, Fan, Songqing. 2024. Itraconazole Reversing Acquired Resistance to Osimertinib in NSCLC by Inhibiting the SHH/DUSP13B/p-STAT3 Axis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 12, e2409416. doi:10.1002/advs.202409416. https://pubmed.ncbi.nlm.nih.gov/39721017/
3. Luo, Jing, Gao, Qiang, Qiu, Hailong, Cen, Jianzheng, Zhuang, Jian. . Myogenin Regulates DUSP13 to Inhibit Apoptosis Induced by Reactive Oxygen Species. In Frontiers in bioscience (Landmark edition), 29, 49. doi:10.31083/j.fbl2902049. https://pubmed.ncbi.nlm.nih.gov/38420814/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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