C57BL/6NCya-Trpa1em1/Cya
Common Name
Trpa1-KO
Product ID
S-KO-08934
Backgroud
C57BL/6NCya
Strain ID
KOCMP-277328-Trpa1-B6N-VA
When using this mouse strain in a publication, please cite “Trpa1-KO Mouse (Catalog S-KO-08934) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Trpa1-KO
Strain ID
KOCMP-277328-Trpa1-B6N-VA
Gene Name
Product ID
S-KO-08934
Gene Alias
Anktm1, TRPA1b
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000041447
NCBI RefSeq
NM_177781
Target Region
Exon 2~7
Size of Effective Region
~9.4 kb
Overview of Gene Research
TRPA1, the transient receptor potential ankyrin 1, is a non-selective cation channel permeable to Ca(2+), Na(+), and K(+). It is a promiscuous chemical nocisensor involved in noxious cold, mechanical sensation, and is present in nociceptive sensory neurons and other cells [2]. TRPA1 has up to 18 N-terminal ankyrin repeats and six membrane-spanning domains. It is well-conserved across species, suggesting an ancestral role in sensation [3].
Preclinical evidence from murine models of pain diseases indicates that oxidative stress and Schwann cell TRPA1 are part of a pathway that sustains chronic pain [1]. In nociceptive neurons of mice, TRPA1 mediates responses to pro-algesic bradykinin and pungent irritants [3]. Also, TRPA1 in immune cells has been linked to conditions like arthritis, anaphylaxis, and atopic dermatitis in murine-related studies, though functional measurements are scarce [4].
In conclusion, TRPA1 plays crucial roles in chemo -, thermo -, and mechano-sensing. Murine models have been instrumental in revealing its role in pain-related diseases and certain immune-mediated conditions. These findings suggest that TRPA1 could be a potential therapeutic target for chronic pain and some inflammatory diseases [1,4].
References:
1. Souza Monteiro de Araujo, Daniel, Nassini, Romina, Geppetti, Pierangelo, De Logu, Francesco. 2020. TRPA1 as a therapeutic target for nociceptive pain. In Expert opinion on therapeutic targets, 24, 997-1008. doi:10.1080/14728222.2020.1815191. https://pubmed.ncbi.nlm.nih.gov/32838583/
2. Zygmunt, Peter M, Högestätt, Edward D. . TRPA1. In Handbook of experimental pharmacology, 222, 583-630. doi:10.1007/978-3-642-54215-2_23. https://pubmed.ncbi.nlm.nih.gov/24756722/
3. García-Añoveros, J, Nagata, K. . TRPA1. In Handbook of experimental pharmacology, , 347-62. doi:. https://pubmed.ncbi.nlm.nih.gov/17217068/
4. Naert, Robbe, López-Requena, Alejandro, Talavera, Karel. 2021. TRPA1 Expression and Pathophysiology in Immune Cells. In International journal of molecular sciences, 22, . doi:10.3390/ijms222111460. https://pubmed.ncbi.nlm.nih.gov/34768891/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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