C57BL/6JCya-Prl5a1em1/Cya
Common Name
Prl5a1-KO
Product ID
S-KO-09003
Backgroud
C57BL/6JCya
Strain ID
KOCMP-28078-Prl5a1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Prl5a1-KO Mouse (Catalog S-KO-09003) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Prl5a1-KO
Strain ID
KOCMP-28078-Prl5a1-B6J-VA
Gene Name
Product ID
S-KO-09003
Gene Alias
Ghd24, PLP-L, Prlpl, D13Wsu14e, 1600013P04Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000017208
NCBI RefSeq
NM_023746
Target Region
Exon 1~5
Size of Effective Region
~9.1 kb
Overview of Gene Research
Prl5a1, a member of the prolactin family, is involved in several biological processes. In the context of placentation, it may play a role in the regulation of the junctional zone. Additionally, it is implicated in uterine development and endometrial adenogenesis [1,2].
In rat placentation studies, Prl5a1 transcript levels were used as a quantitative trait to distinguish strain-specific features. Chromosome-substituted rat strains (with BN chromosomes introgressed into the DSS inbred strain) showed that chromosomes 14 and 17 possess regulatory information controlling Prl5a1 transcript-level quantitative trait related to placentation. In neonatal mouse uterine development, the expression of Prl5a1 increased along with the development of uterine glands, and its expression was suppressed by progesterone injection, indicating its role in endometrial adenogenesis [1,2]. In mouse trophoblast stem cells, overexpression of EGAM1C enhanced the expression levels of Prl5a1, suggesting a potential regulatory role of EGAM1C on Prl5a1 expression [3].
In conclusion, Prl5a1 is important in placental and uterine development. The use of chromosome-substituted rat strains and studies in neonatal mice and trophoblast stem cells have provided insights into its functions. Understanding Prl5a1 may contribute to a better understanding of placental function, uterine development, and potentially related diseases [1,2,3].
References:
1. Konno, Toshihiro, Rempel, Lea A, Rumi, M A Karim, Renaud, Stephen J, Soares, Michael J. 2011. Chromosome-substituted rat strains provide insights into the genetics of placentation. In Physiological genomics, 43, 930-41. doi:10.1152/physiolgenomics.00069.2011. https://pubmed.ncbi.nlm.nih.gov/21652768/
2. Kang, Jinwen, Liu, Yingnan, Zhang, Yu, Wu, Yao, Su, Renwei. 2022. The Influence of the Prolactins on the Development of the Uterus in Neonatal Mice. In Frontiers in veterinary science, 9, 818827. doi:10.3389/fvets.2022.818827. https://pubmed.ncbi.nlm.nih.gov/35252420/
3. Saito, Koichi, Ogawa, Atsushi, Toyofuku, Kyoko, Kojima, Ikuo, Kobayashi, Masayuki. 2010. Relationships between homeoprotein EGAM1C and the expression of the placental prolactin gene family in mouse placentae and trophoblast stem cells. In Reproduction (Cambridge, England), 141, 259-68. doi:10.1530/REP-10-0355. https://pubmed.ncbi.nlm.nih.gov/21084569/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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