Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Gatd3aem1/Cya
Common Name:
Gatd3a-KO
Product ID:
S-KO-09024
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Gatd3a-KO
Strain ID
KOCMP-28295-Gatd3a-B6J-VA
Gene Name
Gatd3a
Product ID
S-KO-09024
Gene Alias
C21orf33; D10Jhu81e; ES1; Gatd3
Background
C57BL/6JCya
NCBI ID
28295
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:1351861
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Gatd3aem1/Cya mice (Catalog S-KO-09024) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000001242
NCBI RefSeq
NM_138601
Target Region
Exon 1~7
Size of Effective Region
~7.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Gatd3a, or glutamine amidotransferase-like class 1 domain-containing 3A, is a mitochondrial protein with significant biological functions. It acts as a deglycase, removing non-enzymatic chemical modifications from nucleotides and amino acids that occur during the Maillard reaction, thus restricting the formation of advanced glycation end products (AGEs) [2]. It may also be involved in maintaining the integrity of important biomolecules in mitochondria through its interactions with factors in mitochondrial mRNA processing and translation [2].

In mouse models, GATD3A deficiency has been shown to have significant impacts. It induces mitochondrial dysfunction in fibroblast-like synoviocytes. Mechanistically, GATD3A deficiency enhances the binding of Sirt3 to MDH2, leading to deacetylation and decreased activity of MDH2. This impairs the tricarboxylic acid cycle flux, resulting in mitochondrial dysfunction and fibroblast-like synoviocyte senescence, which in turn facilitates osteoarthritis progression [1]. Intra-articular injection of recombinant adeno-associated virus carrying GATD3A alleviates the osteoarthritis phenotype in male mice [1]. In shoulder osteoarthritis, GATD3A downregulation is associated with mitochondrial dysfunction and increased cartilage degradation in cuff-tear arthropathy, especially under metabolic syndrome [3].

In conclusion, Gatd3a is crucial for maintaining mitochondrial function by restricting AGE formation. The study of Gatd3a-deficient mouse models has revealed its role in osteoarthritis, highlighting its potential as a therapeutic target for this disease. Understanding Gatd3a's functions contributes to a better understanding of the molecular mechanisms underlying mitochondrial-related pathologies and potential treatment strategies.

References:

1. Shen, Kai, Zhou, Hao, Zuo, Qiang, Zhai, Chenjun, Fan, Weimin. 2024. GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression. In Nature communications, 15, 10923. doi:10.1038/s41467-024-55335-2. https://pubmed.ncbi.nlm.nih.gov/39738099/

2. Smith, Andrew J, Advani, Jayshree, Brock, Daniel C, Kennedy, Breandán, Swaroop, Anand. 2022. GATD3A, a mitochondrial deglycase with evolutionary origins from gammaproteobacteria, restricts the formation of advanced glycation end products. In BMC biology, 20, 68. doi:10.1186/s12915-022-01267-6. https://pubmed.ncbi.nlm.nih.gov/35307029/

3. Lynskey, Samuel J, Ling, Zihui, Ziemann, Mark, McGee, Sean L, Page, Richard S. 2025. Loosening the Lid on Shoulder Osteoarthritis: How the Transcriptome and Metabolic Syndrome Correlate with End-Stage Disease. In International journal of molecular sciences, 26, . doi:10.3390/ijms26073145. https://pubmed.ncbi.nlm.nih.gov/40243895/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest