C57BL/6JCya-Reltem1/Cya
Common Name:
Relt-KO
Product ID:
S-KO-09238
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Relt-KO
Strain ID
KOCMP-320100-Relt-B6J-VA
Gene Name
Product ID
S-KO-09238
Gene Alias
E430021K24Rik; Tnfrsf19l
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
7
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Reltem1/Cya mice (Catalog S-KO-09238) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000008462
NCBI RefSeq
NM_177073
Target Region
Exon 2~11
Size of Effective Region
~5.9 kb
Detailed Document
Overview of Gene Research
RELT, short for Receptor Expressed in Lymphoid Tissues, is a member of the Tumor Necrosis Factor Superfamily. It is involved in cytokine signaling and pathways related to cell death or survival, and plays a role in various biological processes such as cancer development, immune system regulation, and development [1]. The RELT family also includes two paralogs, RELL1 and RELL2.
In mouse models, RELT -/- mice demonstrated that RELT deficiency selectively promotes the homeostatic proliferation of CD4+ T cells and enhances anti-tumor CD8+ T-cell responses, indicating that RELT negatively regulates the early phase of the T-cell response, probably by promoting T-cell apoptosis [2]. In another study, mutations in RELT in humans cause autosomal recessive amelogenesis imperfecta, and Relt -/- mice generated by Nuclease technology showed incisor and molar enamel malformations, suggesting RELT's importance in tooth development [3].
In conclusion, RELT is crucial for immune system regulation and tooth development. The RELT knockout mouse models have provided insights into its role in these biological processes, highlighting its significance in understanding immune-related diseases and amelogenesis imperfecta.
References:
1. Cusick, John K, Alcaide, Jessa, Shi, Yihui. 2023. The RELT Family of Proteins: An Increasing Awareness of Their Importance for Cancer, the Immune System, and Development. In Biomedicines, 11, . doi:10.3390/biomedicines11102695. https://pubmed.ncbi.nlm.nih.gov/37893069/
2. Choi, Beom K, Kim, Seon-Hee, Kim, Young H, Lee, Ho, Kwon, Byoung S. 2018. RELT negatively regulates the early phase of the T-cell response in mice. In European journal of immunology, 48, 1739-1749. doi:10.1002/eji.201847633. https://pubmed.ncbi.nlm.nih.gov/30138536/
3. Kim, Jung-Wook, Zhang, Hong, Seymen, Figen, Simmer, James P, Hu, Jan C-C. 2018. Mutations in RELT cause autosomal recessive amelogenesis imperfecta. In Clinical genetics, 95, 375-383. doi:10.1111/cge.13487. https://pubmed.ncbi.nlm.nih.gov/30506946/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen