C57BL/6JCya-Lrrc58em1/Cya
Common Name:
Lrrc58-KO
Product ID:
S-KO-09258
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Lrrc58-KO
Strain ID
KOCMP-320184-Lrrc58-B6J-VA
Gene Name
Product ID
S-KO-09258
Gene Alias
1810012N18Rik; C330018J07Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
16
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Lrrc58em1/Cya mice (Catalog S-KO-09258) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000078717
NCBI RefSeq
NM_177093
Target Region
Exon 1~4
Size of Effective Region
~13.6 kb
Detailed Document
Overview of Gene Research
Lrrc58, also known as lrr-2 in Caenorhabditis elegans, is involved in sulfur metabolism. It post-translationally regulates the levels of cysteine dioxygenase (cdo-1/CDO1), thus playing a role in cysteine and hydrogen sulfide (H2S) production [2]. In C. elegans, it impacts the interaction with Actinobacteria from its natural microbial environment, as mutations in lrr-2/LRRC58 can affect the growth rate of the nematode on Actinobacteria [2].
In human studies, LRRC58 has been associated with several cancers. In colorectal cancer, it was identified as one of the N6-methyladenosine (m6A)-modified genes related to recurrence, potentially serving as a predictive biomarker or therapeutic target [1]. In prostate cancer, it was part of a set of potential biomarkers proposed for the detection of the disease and discrimination between tumors with different malignancy and aggressiveness, with its methylation being detected in a significant number of prostate tumors [3,4].
In conclusion, LRRC58 plays important roles in biological processes related to sulfur metabolism in C. elegans and is associated with cancer-related processes in humans, especially colorectal and prostate cancers. The identification of its role in these disease-related contexts through various research models provides potential directions for future diagnostic and therapeutic development.
References:
1. Zhu, Qianru, Huang, Xingxing, Yu, Shuxian, Yu, Lili, Wu, Qibiao. 2022. Identification of genes modified by N6-methyladenosine in patients with colorectal cancer recurrence. In Frontiers in genetics, 13, 1043297. doi:10.3389/fgene.2022.1043297. https://pubmed.ncbi.nlm.nih.gov/36324506/
2. Patange, Om, Breen, Peter, Arsuffi, Giulia, Ruvkun, Gary. 2025. Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment. In Cell reports, 44, 115170. doi:10.1016/j.celrep.2024.115170. https://pubmed.ncbi.nlm.nih.gov/39786993/
3. Dmitriev, Alexey A, Rosenberg, Eugenia E, Krasnov, George S, Senchenko, Vera N, Kashuba, Vladimir I. 2015. Identification of Novel Epigenetic Markers of Prostate Cancer by NotI-Microarray Analysis. In Disease markers, 2015, 241301. doi:10.1155/2015/241301. https://pubmed.ncbi.nlm.nih.gov/26491211/
4. Vozianov, S O, Kashuba, V I, Grygorenko, V M, Bondarenko, Yu M, Vikarchuk, M V. . [IDENTIFICATION OF A NEW DIAGNOSTIC MARKERS OF PROSTATIC CANCER, USING NOTI-MICROCHIPS]. In Klinichna khirurhiia, , 54-7. doi:. https://pubmed.ncbi.nlm.nih.gov/27434957/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen