C57BL/6JCya-Prdx6bem1/Cya
Common Name:
Prdx6b-KO
Product ID:
S-KO-09347
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Prdx6b-KO
Strain ID
KOCMP-320769-Prdx6b-B6J-VA
Gene Name
Product ID
S-KO-09347
Gene Alias
1-cysPrx-P1; 4930414C22Rik; Aop2-rs1; Prdx5-rs1; Prdx6-ps1; Prdx6-rs1; Prdx6-rs1-ps
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
2
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Prdx6bem1/Cya mice (Catalog S-KO-09347) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000057072
NCBI RefSeq
NM_177256
Target Region
Exon 1
Size of Effective Region
~1.7 kb
Detailed Document
Overview of Gene Research
Prdx6b is one of the two peroxiredoxins (Prdxs), along with Prdx6A, identified in Trematomus bernacchii, an Antarctic teleost. Prdx6b, like other Prdx6 orthologs, likely has peroxidase and phospholipase activities, which are crucial in antioxidant defense and lipid metabolism pathways, playing an important role in maintaining cellular homeostasis in poikilothermic aquatic vertebrates [1].
In the study of T. bernacchii, the temporal expression of Prdx6 mRNA in response to short-term thermal stress showed a general upregulation of prdx6b, suggesting it may be more responsive in adapting to temperature changes compared to prdx6a. The variations of mRNA accumulation were more conspicuous in the heart than the liver, potentially related to behavioral changes in response to elevated temperature [1].
In conclusion, Prdx6b seems to be involved in the thermal stress response of T. bernacchii, playing a role in helping these poikilothermic aquatic vertebrates adapt to different temperature ranges. The study of Prdx6b in this fish model provides insights into how genes in such organisms evolve and function to adapt to their unique environmental conditions [1].
References:
1. Tolomeo, A M, Carraro, A, Bakiu, R, Ferro, D, Santovito, G. 2015. Peroxiredoxin 6 from the Antarctic emerald rockcod: molecular characterization of its response to warming. In Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 186, 59-71. doi:10.1007/s00360-015-0935-3. https://pubmed.ncbi.nlm.nih.gov/26433650/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen