C57BL/6JCya-Wscd2em1/Cya
Common Name:
Wscd2-KO
Product ID:
S-KO-09363
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Wscd2-KO
Strain ID
KOCMP-320916-Wscd2-B6J-VA
Gene Name
Product ID
S-KO-09363
Gene Alias
4933413A10Rik; C530024P05Rik; Gm450
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Wscd2em1/Cya mice (Catalog S-KO-09363) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000094452
NCBI RefSeq
NM_177292
Target Region
Exon 3
Size of Effective Region
~0.5 kb
Detailed Document
Overview of Gene Research
Wscd2, short for WSC domain-containing 2, is a gene whose exact function is still being elucidated. It has been implicated in multiple biological processes and disease-related pathways. Some studies suggest its potential role in glucose metabolism as it was associated with insulin sensitivity in Mexican-origin Americans [3].
In glioma, WSCD2 mRNA expression in glioma tissues was lower than that in benign brain disease tissues, and high WSCD2 mRNA expression was associated with a favorable outcome. It was also correlated with tumor-infiltrating immune cells (TILs) at the mRNA level, though not at the protein level, and was identified as an independent prognostic factor, suggesting it could be a potential immunotherapy target [1].
In breast cancer, an interaction between a nuSNP in an intron of WSCD2 and a mtSNP was associated with increased nuclei size, and low WSCD2 gene expression coupled with large nuclei was related to an increased risk of mortality in female breast cancer patients, indicating a possible inherent susceptibility to a more severe form of breast cancer [2].
In conclusion, Wscd2 appears to be involved in glioma prognosis and potentially immunotherapy, as well as breast cancer pathology. These findings from human-based research highlight its importance in understanding the molecular mechanisms underlying these diseases and may provide new directions for potential therapeutic strategies.
References:
1. Abudusalam, Kaderya, Xu, Yan, Keyumu, Pazilat, Musha, Kadierjiang, Huang, Jianfei. 2024. WSCD2 Expression: Its Relevance to Tumor-Infiltrating Immune Cells and Glioma Prognosis. In Current medicinal chemistry, , . doi:10.2174/0109298673282921240220101914. https://pubmed.ncbi.nlm.nih.gov/38415455/
2. Bushel, Pierre R, Ward, James, Burkholder, Adam, Li, Jianying, Anchang, Benedict. 2022. Mitochondrial-nuclear epistasis underlying phenotypic variation in breast cancer pathology. In Scientific reports, 12, 1393. doi:10.1038/s41598-022-05148-4. https://pubmed.ncbi.nlm.nih.gov/35082309/
3. Gao, Chuan, Hsu, Fang-Chi, Dimitrov, Latchezar M, Bowden, Donald W, Palmer, Nicholette D. 2017. A genome-wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study. In Genetic epidemiology, 41, 353-362. doi:10.1002/gepi.22042. https://pubmed.ncbi.nlm.nih.gov/28378447/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen