C57BL/6JCya-Wscd2em1/Cya
Common Name
Wscd2-KO
Product ID
S-KO-09363
Backgroud
C57BL/6JCya
Strain ID
KOCMP-320916-Wscd2-B6J-VA
When using this mouse strain in a publication, please cite “Wscd2-KO Mouse (Catalog S-KO-09363) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Wscd2-KO
Strain ID
KOCMP-320916-Wscd2-B6J-VA
Gene Name
Product ID
S-KO-09363
Gene Alias
Gm450, 4933413A10Rik, C530024P05Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000094452
NCBI RefSeq
NM_177292
Target Region
Exon 3
Size of Effective Region
~0.5 kb
Overview of Gene Research
Wscd2, short for WSC domain-containing 2, is a gene whose exact function is still being elucidated. It has been implicated in multiple biological processes and disease-related pathways. Some studies suggest its potential role in glucose metabolism as it was associated with insulin sensitivity in Mexican-origin Americans [3].
In glioma, WSCD2 mRNA expression in glioma tissues was lower than that in benign brain disease tissues, and high WSCD2 mRNA expression was associated with a favorable outcome. It was also correlated with tumor-infiltrating immune cells (TILs) at the mRNA level, though not at the protein level, and was identified as an independent prognostic factor, suggesting it could be a potential immunotherapy target [1].
In breast cancer, an interaction between a nuSNP in an intron of WSCD2 and a mtSNP was associated with increased nuclei size, and low WSCD2 gene expression coupled with large nuclei was related to an increased risk of mortality in female breast cancer patients, indicating a possible inherent susceptibility to a more severe form of breast cancer [2].
In conclusion, Wscd2 appears to be involved in glioma prognosis and potentially immunotherapy, as well as breast cancer pathology. These findings from human-based research highlight its importance in understanding the molecular mechanisms underlying these diseases and may provide new directions for potential therapeutic strategies.
References:
1. Abudusalam, Kaderya, Xu, Yan, Keyumu, Pazilat, Musha, Kadierjiang, Huang, Jianfei. 2024. WSCD2 Expression: Its Relevance to Tumor-Infiltrating Immune Cells and Glioma Prognosis. In Current medicinal chemistry, , . doi:10.2174/0109298673282921240220101914. https://pubmed.ncbi.nlm.nih.gov/38415455/
2. Bushel, Pierre R, Ward, James, Burkholder, Adam, Li, Jianying, Anchang, Benedict. 2022. Mitochondrial-nuclear epistasis underlying phenotypic variation in breast cancer pathology. In Scientific reports, 12, 1393. doi:10.1038/s41598-022-05148-4. https://pubmed.ncbi.nlm.nih.gov/35082309/
3. Gao, Chuan, Hsu, Fang-Chi, Dimitrov, Latchezar M, Bowden, Donald W, Palmer, Nicholette D. 2017. A genome-wide linkage and association analysis of imputed insertions and deletions with cardiometabolic phenotypes in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study. In Genetic epidemiology, 41, 353-362. doi:10.1002/gepi.22042. https://pubmed.ncbi.nlm.nih.gov/28378447/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.