Acot11, also known as Thioesterase superfamily member 1, encodes enzymes that hydrolyze fatty acyl-CoA esters into free fatty acids and CoA. It is involved in fatty acid metabolism, which is essential for energy production, cell membrane synthesis, and cell signaling [3,6].

In lung adenocarcinoma, high expression of Acot11 is associated with poor prognosis. Knocking down Acot11 in vitro and in vivo inhibits cell proliferation, migration, and invasion, while promoting apoptosis and cell cycle arrest via multiple signaling pathways. It was also found that Acot11 can bind with CSE1L, an oncogene in lung cancer [1]. In clear cell renal cell carcinoma (ccRCC), Acot11 is significantly downregulated and has a high diagnostic value. In idiopathic pulmonary fibrosis, a prognostic model incorporating Acot11 shows potential clinical utility. In early-stage lung squamous cell carcinoma, a gene signature including Acot11 can predict prognosis, immune landscape, and drug sensitivity [2,4,5].

In conclusion, Acot11 plays a crucial role in fatty acid metabolism. Its dysregulation is associated with various diseases, especially lung cancers and ccRCC. Studies using gene knockdown (a form of in-vivo loss-of-function experiment) have revealed its role in promoting cancer cell proliferation, migration, and invasion, providing insights into potential molecular therapy targets [1,2].

References:

1. Liang, Chaoyang, Wang, Xiaowei, Zhang, Zhenrong, Zhong, Dingrong, Liu, Deruo. . ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma. In Translational lung cancer research, 9, 1885-1903. doi:10.21037/tlcr-19-509. https://pubmed.ncbi.nlm.nih.gov/33209610/

2. Xu, Chao-Liang, Chen, Lei, Li, Deng, Sha, Ming-Lei, Shao, Yi. 2020. Acyl-CoA Thioesterase 8 and 11 as Novel Biomarkers for Clear Cell Renal Cell Carcinoma. In Frontiers in genetics, 11, 594969. doi:10.3389/fgene.2020.594969. https://pubmed.ncbi.nlm.nih.gov/33362855/

3. Little, Molly, Ortlund, Eric A. . Structure, function, and lipid sensing activity in the thioesterase superfamily. In Biochemical Society transactions, 52, 1565-1577. doi:10.1042/BST20230313. https://pubmed.ncbi.nlm.nih.gov/39140379/

4. Wang, Xuewen, Yang, Luqin, Wang, Yuxuan, Wang, Ke, Zhang, Huilan. 2024. Establishment and validation of a prognostic model for idiopathic pulmonary fibrosis based on mitochondrial-related genes. In Journal of thoracic disease, 16, 7427-7445. doi:10.21037/jtd-24-760. https://pubmed.ncbi.nlm.nih.gov/39678889/

5. Xu, Juqing, Yu, Maoran, Fan, Weifei, Feng, Jifeng. 2024. A novel gene signature related to fatty acid metabolism predicts prognosis, immune landscape, and drug sensitivity in early-stage lung squamous cell carcinoma. In Translational cancer research, 13, 525-541. doi:10.21037/tcr-23-1640. https://pubmed.ncbi.nlm.nih.gov/38482436/

6. Cohen, David E. . New players on the metabolic stage: How do you like Them Acots? In Adipocyte, 2, 3-6. doi:. https://pubmed.ncbi.nlm.nih.gov/23700546/