C57BL/6NCya-Kcpem1/Cya
Common Name
Kcp-KO
Product ID
S-KO-09580
Backgroud
C57BL/6NCya
Strain ID
KOCMP-333088-Kcp-B6N-VA
Status
When using this mouse strain in a publication, please cite “Kcp-KO Mouse (Catalog S-KO-09580) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Kcp-KO
Strain ID
KOCMP-333088-Kcp-B6N-VA
Gene Name
Product ID
S-KO-09580
Gene Alias
Crim2, Gm793, KCP-1, CRIM-2
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6 (Mouse)
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Transcript ID
ENSMUST00000101614
NCBI Transcript ID
NM_001029985
Target Region
Exon 2~8
Size of Effective Region
~4.6 kb
Overview of Gene Research
Kcp, also known as kielin/chordin-like protein, is a large secreted protein. It can enhance bone morphogenetic protein (BMP) signaling while suppressing TGF-β signaling, and is involved in the regulation of pathways related to lipid deposition and adipose tissue differentiation [1,2]. Kcp is of biological importance as it impacts physiological processes such as metabolism and is associated with diseases like non-alcoholic fatty liver disease (NAFLD) and obesity. Genetic models, especially mouse models, are valuable for studying Kcp's functions.
In gene knockout (KO) mouse models, aging Kcp-/-mice are more susceptible to developing hepatic steatosis and liver fibrosis, and when on a high-fat diet, young Kcp-/-mice are more prone to liver pathology compared to wild-type littermates [1]. On the other hand, mice expressing a Pepck-KCP transgene in the liver are resistant to high-fat diet-induced liver pathology. Also, Kcp-/-mice are more sensitive to obesity, glucose intolerance, adipose tissue inflammation and fibrosis, while transgenic mice overexpressing Kcp in the kidney, liver, and adipose tissues are resistant to high-fat diet-induced obesity with reduced white adipose tissue [2].
In conclusion, through model-based research, Kcp has been shown to play essential roles in regulating lipid metabolism in the liver and obesity-related metabolic processes. The KO mouse models have contributed significantly to understanding Kcp's role in NAFLD and obesity, providing insights into the underlying molecular mechanisms and potential therapeutic targets for these disease areas.
References:
1. Soofi, Abdul, Wolf, Katherine I, Ranghini, Egon J, Amin, Mohammad A, Dressler, Gregory R. 2016. The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice. In American journal of physiology. Gastrointestinal and liver physiology, 311, G587-G598. doi:10.1152/ajpgi.00165.2016. https://pubmed.ncbi.nlm.nih.gov/27514479/
2. Soofi, Abdul, Wolf, Katherine I, Emont, Margo P, Ostwani, Wesam, Dressler, Gregory R. 2017. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. In The Journal of biological chemistry, 292, 9051-9062. doi:10.1074/jbc.M116.771428. https://pubmed.ncbi.nlm.nih.gov/28424263/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
